Co-expression Network analysis identifies the Brown module as related to Atherosclerosis. (A). Mean MS score for each of the 11 network modules. (B) Mean module gene expression in atherosclerotic aorta tissue relative to non-atherosclerotic tissue at 6 weeks. (C) Mean module gene expression in atherosclerotic aorta tissue relative to non-atherosclerotic tissue at 36 weeks. In panels (B–C) expression is presented as the mean log2 expression for each gene in a module in aorta from C57BL/6 J Apoe
-/- mice minus log2 expression from wild type C57BL/6 J mice. (D) A sub-network of co-expressed genes in the Brown Module including Cd44 and the brown module hub genes. Gene connectivity determines size of each node. Distance between nodes is determined by the topological overlap. * denotes significant differences (p < 0.05).