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Table 2 Hub Genes in brown module

From: Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

Gene symbol Gene name Chr Mb Kme Expression regulated by
Chr 2: eQTL
Role in atherosclerosis Role in monocyte derived cells Known candidate for human disease Leo score RMSEA
Nckap1l (Hem-1) NCK associated protein 1 like 15 103 1 Yes (6.18) None Known Yes [44] None Known -1.22 0.255
105.89 Mb
Evl Ena-vasodilator stimulated phosphoprotein 12 108 0.93 Yes (6.17) None Known None leukocyte adhesion deficiency -1.46 0. 280
84.17 Mb
Apbb1ip (RIAM) amyloid beta (A4) precursor protein-binding, family 2 23 0.92 Yes (7.86) None Known Yes phagocytosis [45] None Known -21.27 0. 255
81.80 Mb
Fermt3 fermitin family homolog 3 19 7 0.88 Yes (7.73) None Known Yes [46] leukocyte adhesion deficiency -0.49 0.223
105.89 Mb
Ncf2 neutrophil cytosolic factor 2 1 153 0.85 Yes (4.23) None Known Yes [47] Chronic granulomatous disease -1.87 0.283
84.17 Mb
Trpv2 transient receptor potential cation channel, subfamily V, member 2 11 63 0.83 Yes (8.19) None Known Yes-cell death in response to oxidized LDL [48, 49] None Known -1.38 0.275
148.90 Mb
Gpsm3 G-protein signaling modulator 3 17 34 0.82 Yes (5.81) None Known Yes [50] None Known -1.76 0.28
105.89 Mb
Was Wiskott-Aldrich syndrome homolog X 8 0.81 none   Yes [51] Wiskott-Aldrich syndrome -1.33 0.268
Plcg2 phospholipase C, gamma 2 8 117 0.80 Yes (7.38) None Known Yes [52, 53] Familial cold autoinflammatory syndrome -0.98 0.254
105.89 Mb
Cd44 CD44 antigen 2 102 0.26 Yes Yes Yes None Known 1.01 0.000
  1. Kme- is the weighted connectivity for the gene. LEO.NB, log10 ratio of causal model to all other model probabilities; -log10P, RMSEA, a model fit index (index close to 0 indicates good fit of the causal model).