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Table 2 Hub Genes in brown module

From: Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

Gene symbol

Gene name

Chr

Mb

Kme

Expression regulated by

Chr 2: eQTL

Role in atherosclerosis

Role in monocyte derived cells

Known candidate for human disease

Leo score

RMSEA

Nckap1l (Hem-1)

NCK associated protein 1 like

15

103

1

Yes (6.18)

None Known

Yes [44]

None Known

-1.22

0.255

105.89 Mb

Evl

Ena-vasodilator stimulated phosphoprotein

12

108

0.93

Yes (6.17)

None Known

None

leukocyte adhesion deficiency

-1.46

0. 280

84.17 Mb

Apbb1ip (RIAM)

amyloid beta (A4) precursor protein-binding, family

2

23

0.92

Yes (7.86)

None Known

Yes phagocytosis [45]

None Known

-21.27

0. 255

81.80 Mb

Fermt3

fermitin family homolog 3

19

7

0.88

Yes (7.73)

None Known

Yes [46]

leukocyte adhesion deficiency

-0.49

0.223

105.89 Mb

Ncf2

neutrophil cytosolic factor 2

1

153

0.85

Yes (4.23)

None Known

Yes [47]

Chronic granulomatous disease

-1.87

0.283

84.17 Mb

Trpv2

transient receptor potential cation channel, subfamily V, member 2

11

63

0.83

Yes (8.19)

None Known

Yes-cell death in response to oxidized LDL [48, 49]

None Known

-1.38

0.275

148.90 Mb

Gpsm3

G-protein signaling modulator 3

17

34

0.82

Yes (5.81)

None Known

Yes [50]

None Known

-1.76

0.28

105.89 Mb

Was

Wiskott-Aldrich syndrome homolog

X

8

0.81

none

 

Yes [51]

Wiskott-Aldrich syndrome

-1.33

0.268

Plcg2

phospholipase C, gamma 2

8

117

0.80

Yes (7.38)

None Known

Yes [52, 53]

Familial cold autoinflammatory syndrome

-0.98

0.254

105.89 Mb

Cd44

CD44 antigen

2

102

0.26

Yes

Yes

Yes

None Known

1.01

0.000

  1. Kme- is the weighted connectivity for the gene. LEO.NB, log10 ratio of causal model to all other model probabilities; -log10P, RMSEA, a model fit index (index close to 0 indicates good fit of the causal model).