Pedigree of a three-generation family of case 1. Circles denote female subjects, squares denote male subjects, and symbols with diagonals denote dead subjects. The CJD allele status is explained in legend located in the upper right panel. The proband is marked with a black arrow. The age of each individual is noted in each symbol, and year of birth is noted upper part of each symbol. Died individuals were denoted as “X in a square” and their ages at death are shown above the square.