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Table 1 The information of the 24 sites that were directly sequenced and the genotypes of analysed individuals

From: Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation

     PRNP mutation E200K E200K E200K E200K WT E200K E200K E200K WT E200K WT E200K WT E200K WT WT WT WT WT WT E219K WT WT WT WT
     Sample ID Patient no. 1 Patient no. 2 Patient no. 3 Family no. 1 Family no. 2 Family no. 3 Family no. 4 Family no. 5 Family no. 6 Family no. 7 Family no. 8 Family no. 9 Family no. 10 Family no. 11 Family no. 12 Normal no. 1 Normal no. 2 Normal no. 3 Normal no. 4 Normal no. 5 Normal no. 6 Normal no. 7 Normal no. 8 Normal no. 9 Normal no. 10
Variants filtering strategy Chr. Position Gene Year of birth Ref./Obs. 1948 non-descript 1935 1927 1950 1952 1955 1957 1962 1969 1971 1975 1977 1981 1983 1969 1975 1976 1977 1980 1982 1983 1983 1984 1987
Filtering strategy 1 1 27,268,000 NUDC G/A GG GG GG GA GG GA GA GA GG GG GG GG GG GA GG GG GG GG GG GG GG GG GG GG GG
1 42,049,603 HIVEP3 C/T CC CC CC CT CT CC CC CC CT CC CC CC CC CC CC CC CT CC CC CC CC CC CC CC CC
2 64,199,317 VPS54 G/A GG GG GG GA GG GG GA GA GA GG GG GG GA GA GG GG GG GA GG GG GG GG GG GG GG
2 233,346,498 ECEL1 C/T CC CC CC CT CC CC CC CC CT CC CC CC CC CC CC CC CT CC CC CT CT CC CC CC CC
3 124,896,625 SLC12A8 A/G AA AA AA AG AG AA AG AG AA AA AA AA AG AG AG AA AA AA AA AA AA AA AA AA AA
4 187,153,290 KLKB1 C/T CC CC CC CT CC CC CT CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC
5 139,884,478 ANKHD1-EIF4EBP3 G/C GG GG GG GC GG GG GG GG GC GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG
6 159,185,617 SYTL3 T/C TT TT TT TC TC TC TT TC TT TT TT TT TT TC TC TT TT TT TT TT TT TT TT TT TT
8 2,088,717 MYOM2 G/T GG GG GG GT GT GT GT GG GT GG GG GG GT GG GG GG GG GG GG GG GG GG GG GG GG
9 18,950,859 FAM154A C/T CC CC CC CT CT CT CT CC CT CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC
10 24,831,649 KIAA1217 C/T CC CC CC CT CT CT CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC
11 27,016,411 FIBIN A/G AA AA AA AG FL AA AG AG AG AA AA AA AA AG AA AA AA AG AA AA AA AA AA AA AG
11 36,250,774 LDLRAD3 G/T GG GG GG GT GG GT GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG
11 64,453,195 NRXN2 C/A CC CC CC CA CC CA CA CA CC CC CC CC CC CA CC CC CC CC CC CC CC CC CC CC CC
13 39,588,100 PROSER1 G/A GG GG GG GA GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG
16 75,669,878 KARS A/G AA AA AA AG AG AA AA AG AA AA AA AA AA AA AG AA AA AA AA AA AA AA AA AA AA
17 59,489,425 C17orf82 C/G CC CC CC CG CG CG CC CG CG CC CC CC CC CC CG CC CC CC CC CC CC CC CC CC CC
18 21,485,578 LAMA3 G/C GG GG GG GC GC GC GC GG GC GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG GG
19 4,359,190 MPND C/T CC CC CC CT CT CT CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC
Filtering strategy 2 17 45,219,336 CDC27 T/A TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT
19 501,786 MADCAM1 C/A CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC CC
19 50,510,999 VRK3 A/T TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT
19 50,511,000 C/T TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT TT
  19 52,096,053 AC018755.11 T/A TA TA TA AA TA TA TA TA TA AA TA TT TA TA TA AA TA TA TT AA TT TA TA TA TT