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Table 1 Characteristics of the study population

From: Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study

 

Non-survivors

Survivors

Variable

Mean/Median

SEM/IQR/%

Mean/Median

SEM/IQR/%

Women (n/%)

36

73.5

70

68.6

Age (months)

1079.7

0.52

1079.9

0.32

Systolic blood pressure (mmHg)

141

3.75

150

2.92

Diastolic blood pressure (mmHg)*

70.5

14.5

74.5

19.0

Weight (kg)

63.3

1.96

70.0

1.32

BMI (kg/m2)

24.8

0.67

27.1

0.46

Waist circumference (cm)

89.4

1.93

94.0

1.25

Hip circumference (cm)*

98.5

11.0

102

11.5

MMSE*

24.0

7.0

26.0

4.0

Barthel index*

95.0

20.0

97.5

5.0

Handgrip (kg)*

18.0

10.5

20.0

6.5

Able to perform chair-rise test (n = yes/%)

29

63.0

82

80.4

Able to perform chair-stand test (n = yes/%)

32

72.7

87

86.1

Frailty index (n/%)

    

Non-frail

3

6.1

35

34.3

Pre-frail

32

65.3

52

51.0

Frail

14

28.6

15

14.7

CRP level (ng/ml)*

2.2

7.5

2.0

3.2

IL-1β level (pg/ml)*

14.4

27.4

20.9

33.5

IL-6 level (pg/ml)*

4.9

3.1

3.8

3.9

IL-7 level (pg/ml)*

8.0

4.5

7.5

5.4

IL-10 level (pg/ml)*

1.56

1.23

1.52

1.62

cf-DNA level (μg/ml)*

0.92

0.21

0.87

0.17

Unmethylated cf-DNA level (μg/ml)*

0.73

0.20

0.67

0.16

Plasma mtDNA (copy number)*

4.27E8

2.68E8

3.64E8

2.32E8

Alu repeat cf-DNA (GE)*

80.2

62.7

66.5

38.3

DHEAS (μg/ml)*

0.25

0.48

0.24

0.29

Cortisol (ng/ml)*

133

55.9

125

60.9

IDO activity (Kyn/Trp)*

52.7

23.3

50.8

23.2

Anti-CMV antibody titer

19200

1145

19141

830

Anti-EBV antibody titer*

410

310

385

380

CD3+ cells (%)*a

60.9

21.5

57.0

13.8

CD4+ cells (%)b

62.3

2.38

63.6

1.42

CD8+ cells (%)b

31.0

2.21

29.2

1.33

CD4+/CD8+ cells (ratio)*

2.29

2.40

2.29

2.38

CD4+CD28- cells (%)*c

11.0

17.0

10.0

12.0

CD8+CD28- cells (%)*d

65.2

29.4

69.1

23.7

CD14+ cells (%)*a

9.5

8.6

9.5

6.4

  1. *median value and IQR presented.
  2. apercentage of live-gated cells, bpercentage of total T lymphocytes (CD3+ cells),
  3. cpercentage of CD4+ cells, dpercentage of CD8+ cells.
  4. Abbreviations: BMI body mass index, CD cluster of differentiation, CMV cytomegalovirus, CRP C-reactive protein, cf-DNA cell-free DNA, DHEAS dehydroepiandrosterone sulphate, EBV Epstein-Barr virus, GE genomic equivalent, IDO indoleamine 2,3-dioxygenase, IL interleukin, Kyn kynurenine, MMSE Mini-Mental State Examination, mtDNA mitochondrial DNA, Trp tryptophan.