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Table 1 Characteristics of the study population

From: Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study

  Non-survivors Survivors
Variable Mean/Median SEM/IQR/% Mean/Median SEM/IQR/%
Women (n/%) 36 73.5 70 68.6
Age (months) 1079.7 0.52 1079.9 0.32
Systolic blood pressure (mmHg) 141 3.75 150 2.92
Diastolic blood pressure (mmHg)* 70.5 14.5 74.5 19.0
Weight (kg) 63.3 1.96 70.0 1.32
BMI (kg/m2) 24.8 0.67 27.1 0.46
Waist circumference (cm) 89.4 1.93 94.0 1.25
Hip circumference (cm)* 98.5 11.0 102 11.5
MMSE* 24.0 7.0 26.0 4.0
Barthel index* 95.0 20.0 97.5 5.0
Handgrip (kg)* 18.0 10.5 20.0 6.5
Able to perform chair-rise test (n = yes/%) 29 63.0 82 80.4
Able to perform chair-stand test (n = yes/%) 32 72.7 87 86.1
Frailty index (n/%)     
Non-frail 3 6.1 35 34.3
Pre-frail 32 65.3 52 51.0
Frail 14 28.6 15 14.7
CRP level (ng/ml)* 2.2 7.5 2.0 3.2
IL-1β level (pg/ml)* 14.4 27.4 20.9 33.5
IL-6 level (pg/ml)* 4.9 3.1 3.8 3.9
IL-7 level (pg/ml)* 8.0 4.5 7.5 5.4
IL-10 level (pg/ml)* 1.56 1.23 1.52 1.62
cf-DNA level (μg/ml)* 0.92 0.21 0.87 0.17
Unmethylated cf-DNA level (μg/ml)* 0.73 0.20 0.67 0.16
Plasma mtDNA (copy number)* 4.27E8 2.68E8 3.64E8 2.32E8
Alu repeat cf-DNA (GE)* 80.2 62.7 66.5 38.3
DHEAS (μg/ml)* 0.25 0.48 0.24 0.29
Cortisol (ng/ml)* 133 55.9 125 60.9
IDO activity (Kyn/Trp)* 52.7 23.3 50.8 23.2
Anti-CMV antibody titer 19200 1145 19141 830
Anti-EBV antibody titer* 410 310 385 380
CD3+ cells (%)*a 60.9 21.5 57.0 13.8
CD4+ cells (%)b 62.3 2.38 63.6 1.42
CD8+ cells (%)b 31.0 2.21 29.2 1.33
CD4+/CD8+ cells (ratio)* 2.29 2.40 2.29 2.38
CD4+CD28- cells (%)*c 11.0 17.0 10.0 12.0
CD8+CD28- cells (%)*d 65.2 29.4 69.1 23.7
CD14+ cells (%)*a 9.5 8.6 9.5 6.4
  1. *median value and IQR presented.
  2. apercentage of live-gated cells, bpercentage of total T lymphocytes (CD3+ cells),
  3. cpercentage of CD4+ cells, dpercentage of CD8+ cells.
  4. Abbreviations: BMI body mass index, CD cluster of differentiation, CMV cytomegalovirus, CRP C-reactive protein, cf-DNA cell-free DNA, DHEAS dehydroepiandrosterone sulphate, EBV Epstein-Barr virus, GE genomic equivalent, IDO indoleamine 2,3-dioxygenase, IL interleukin, Kyn kynurenine, MMSE Mini-Mental State Examination, mtDNA mitochondrial DNA, Trp tryptophan.