Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study

Table 2 Mortality-predicting variables

	Univariate		Multivariate
	HR (95% CI)	p	HR (95% CI)	p
Systolic blood pressure	0.99 (0.98-1.00)	0.039
Diastolic blood pressure	0.97 (0.95-1.00)	0.031
Weight	0.97 (0.94-0.99)	0.003
BMI	0.90 (0.84-0.97)	0.004	0.91 (0.85-0.97)	0.007
Hip circumference	0.95 (0.92-0.99)	0.010
MMSE	0.91 (0.87-0.95)	<0.001
Barthel index	0.97 (0.96-0.99)	<0.001
Handgrip	0.95 (0.91-0.99)	0.010
Able to perform chair-rise test (ref. = no)	0.41 (0.23-0.73)	0.002
Able to perform chair-stand test (ref. = no)	0.39 (0.22-0.71)	0.002
cf-DNA level	5.17 (1.64-16.4)	0.005	3.82 (1.18-12.3)	0.025
Unmethylated cf-DNA level	5.28 (1.62-17.2)	0.006
Frailty index (ref. = non-frail)
Pre-frail	5.90 (1.80-19.3)	0.003	5.35 (1.63-17.6)	0.006
Frail	8.46 (2.43-29.5)	0.001	6.29 (1.77-22.4)	0.005

Abbreviations: BMI body mass index, cf-DNA cell-free DNA, CI confidence interval, HR hazard ratio, MMSE Mini-Mental State Examination.
The variables predicting mortality in the Cox univariate assessment are presented on the left side of the table and the variables remaining as independent predictors in the stepwise Cox multivariate model are presented on the right side of the table.

ISSN: 1755-8794