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Table 2 Mortality-predicting variables

From: Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study

  Univariate Multivariate
  HR (95% CI) p HR (95% CI) p
Systolic blood pressure 0.99 (0.98-1.00) 0.039   
Diastolic blood pressure 0.97 (0.95-1.00) 0.031   
Weight 0.97 (0.94-0.99) 0.003   
BMI 0.90 (0.84-0.97) 0.004 0.91 (0.85-0.97) 0.007
Hip circumference 0.95 (0.92-0.99) 0.010   
MMSE 0.91 (0.87-0.95) <0.001   
Barthel index 0.97 (0.96-0.99) <0.001   
Handgrip 0.95 (0.91-0.99) 0.010   
Able to perform chair-rise test (ref. = no) 0.41 (0.23-0.73) 0.002   
Able to perform chair-stand test (ref. = no) 0.39 (0.22-0.71) 0.002   
cf-DNA level 5.17 (1.64-16.4) 0.005 3.82 (1.18-12.3) 0.025
Unmethylated cf-DNA level 5.28 (1.62-17.2) 0.006   
Frailty index (ref. = non-frail)     
Pre-frail 5.90 (1.80-19.3) 0.003 5.35 (1.63-17.6) 0.006
Frail 8.46 (2.43-29.5) 0.001 6.29 (1.77-22.4) 0.005
  1. Abbreviations: BMI body mass index, cf-DNA cell-free DNA, CI confidence interval, HR hazard ratio, MMSE Mini-Mental State Examination.
  2. The variables predicting mortality in the Cox univariate assessment are presented on the left side of the table and the variables remaining as independent predictors in the stepwise Cox multivariate model are presented on the right side of the table.