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Table 3 The 10 most significant mortality-associated canonical pathways

From: Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study

Ingenuity canonical pathway -log(p)* Ratio Transcripts
LPS-stimulated MAPK Signaling 2.97 0.11 NFKBIA, MAP2K2, PIK3C3, RAC1, MAPK9, IKBKE, MAP2K3, ELK1, PRKCB
CD28 Signaling in T Helper Cells 2.68 0.08 CALM1 (includes others), NFKBIA, MAP2K2, PIK3C3, HLA-DRA, RAC1, MAPK9, CD86, IKBKE, ARPC4
B Cell Receptor Signaling 2.33 0.07 CALM1 (includes others), NFKBIA, MAP2K2, PIK3C3, RAC1, MAPK9, IKBKE, MAP2K3, INPP5K, ELK1, PRKCB
CD40 Signaling 2.33 0.10 NFKBIA, MAP2K2, LTA, PIK3C3, MAPK9, IKBKE, MAP2K3
Pyridoxal 5′-phosphate Salvage Pathway 2.33 0.11 MAP2K2, PIM1, GRK6, CDK6, MAPK9, MAP2K3, IRAK1
Natural Killer Cell Signaling 2.33 0.08 KIR2DL1/KIR2DL3, KIR3DL1, MAP2K2, PIK3C3, RAC1, INPP5K, KIR2DL4, SH2D1B, PRKCB
IL-1 Signaling 2.22 0.08 TOLLIP, NFKBIA, MAPK9, IKBKE, MAP2K3, GNA13, PRKAR1A, IRAK1
Salvage Pathways of Pyrimidine Ribonucleotides 2.22 0.09 NME4, MAP2K2, PIM1, GRK6, CDK6, MAPK9, MAP2K3, IRAK1
CD27 Signaling in Lymphocytes 2.15 0.11 SIVA1, NFKBIA, MAP2K2, MAPK9, IKBKE, MAP2K3
PI3K Signaling in B Lymphocytes 2.15 0.07 CALM1 (includes others), NFKBIA, MAP2K2, FOXO3, RAC1, IKBKE, PLEKHA1, ELK1, PRKCB
  1. *Benjamini-Hochberg -corrected p-value.
  2. The presented pathways are generated from the 331 transcripts that predicted mortality independent of BMI, frailty index and cf-DNA level.