CROSS-STUDIES accuracy of mechanism identification methods using their default parameters. Strong overlap performance of N-of-1-pathways method. We compared the three different mechanism identification methods (N-of-1-pathways) across the three different studies (neuronal, breast and ovarian cancer cell lines). The computed overlaps of PTBP1-KD associated mechanisms are represented by Venn Diagrams. Odds Ratio (OR) and p-values (p) are plotted below the Venn Diagrams to represent the statistical significance of the overlap (Methods). The symbol "X" marked in the GSEA results represents not computed analysis, as this method cannot be applied to the single paired sample form the neuronal cell line dataset I.