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Table 3 Concordance of regulated mechanisms by PTBP1 across three cell lines (neuronal, breast cancer and ovarian cell lines) discovered by N-of-1-pathways.

From: Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

GO-BP Classes

GO-BP Overlap

GO-BP ITS ≥ 0.7

RNA splicing/RNA processing

GO:0008380

RNA splicing

GO:0000398

mRNA splicing, via spliceosome

 

GO:0006397

mRNA processing

GO:0000375

RNA splicing, via transesterification reactions

   

GO:0000377

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

   

GO:0016071

mRNA metabolic process

   

GO:0034470

ncRNA processing

   

GO:0006364

rRNA processing

Cell cycle/cell division

GO:0007067

mitosis

GO:0000279

M phase

 

GO:0051301

cell division

GO:0000216

M/G1 transition of mitotic cell cycle

 

GO:0000280

nuclear division

GO:0000082

G1/S transition of mitotic cell cycle

 

GO:0000087

M phase of mitotic cell cycle

GO:0000086

G2/M transition of mitotic cell cycle

 

GO:0051325

interphase

GO:0000236

mitotic prometaphase

 

GO:0051329

interphase of mitotic cell cycle

GO:0051320

S phase

 

GO:0006260

DNA replication

GO:0000084

S phase of mitotic cell cycle

 

GO:0007059

chromosome segregation

GO:0000819

sister chromatid segregation

 

GO:0071156

regulation of cell cycle arrest

GO:0006261

DNA-dependent DNA replication

 

GO:0010564

regulation of cell cycle process

GO:0000070

mitotic sister chromatid segregation

 

GO:0000075

cell cycle checkpoint

GO:0007093

mitotic cell cycle checkpoint

 

GO:0000226

microtubule cytoskeleton organization

GO:0045786

negative regulation of cell cycle

 

GO:0007017

microtubule-based process

GO:0010948

negative regulation of cell cycle process

 

GO:0048285

organelle fission

GO:0007346

regulation of mitotic cell cycle

   

GO:0051439

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

   

GO:0031023

microtuble organizing center organization

   

GO:0051327

M phase of meitic cell cycle

   

GO:0007051

spindle organization

   

GO:0007126

meiosis

   

GO:0051321

meiotic cell cycle

Chromatin modifications/ remodeling

  

GO:0016568

chromatin modification

   

GO:0006325

chromatin organization

   

GO:0016569

covalent chromatin modification

   

GO:0016570

histone modification

   

GO:0051052

regulation of DNA metabolic process

DNA repair

GO:0006310

DNA recombination

GO:0006974

response to DNA damage stimulus

 

GO:0006281

DNA repair

GO:0006302

double-strand break repair

Neuronal process

  

GO:0031644

regulation of neurological system process

   

GO:0007268

synaptic transmission

   

GO:0050804

regulation of synaptic transmission

   

GO:0051969

regulation of transmission of nerve impulse

Others

  

GO:0007600

sensory perception