Identification of novel therapeutics for complex diseases from genome-wide association data

BMC Medical Genomics

Table 1 Repositioning potential and known therapeutic targets by phenotype.

PH	≠ TT	TI	RN	RTT	NTT	NV	RN
T2D	84	0.29	5^th	7	77	0.92	5^th
T1D	97	0.27	6^th	2	95	0.98	2^nd
RA	77	0.38	2^nd	6	71	0.92	5^th
HT	78	0.35	4^th	5	73	0.94	4^th
BD	59	0.27	6^th	1	58	0.98	2^nd
CD	135	0.36	3^rd	0	135	1.00	1^st
CAD	102	0.39	1^st	4	98	0.96	3^rd

Abbreviations - PH - Phenotypes; ≠TT - Number of Therapeutic Targets; TI - Targetability Index; NTT - Novel Therapeutic Targets; RTT - Replicated Therapeutic Targets; NV - Novelty; RN - Rank; T2D - Type 2 Diabetes; BD - Bipolar Disorder; CD - Crohn's Disease; HT - Hypertension; T1D - Type 1 Diabetes; CAD - Coronary Artery Disease; RA - Rheumatoid Arthritis.
Description of therapeutic targets and novel therapeutic targets. Total 452 unique therapeutic targets and total 428 unique novel therapeutic targets obtained for seven complex diseas

ISSN: 1755-8794