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Table 1 Repositioning potential and known therapeutic targets by phenotype.

From: Identification of novel therapeutics for complex diseases from genome-wide association data

PH ≠ TT TI RN RTT NTT NV RN
T2D 84 0.29 5th 7 77 0.92 5th
T1D 97 0.27 6th 2 95 0.98 2nd
RA 77 0.38 2nd 6 71 0.92 5th
HT 78 0.35 4th 5 73 0.94 4th
BD 59 0.27 6th 1 58 0.98 2nd
CD 135 0.36 3rd 0 135 1.00 1st
CAD 102 0.39 1st 4 98 0.96 3rd
  1. Abbreviations - PH - Phenotypes; ≠TT - Number of Therapeutic Targets; TI - Targetability Index; NTT - Novel Therapeutic Targets; RTT - Replicated Therapeutic Targets; NV - Novelty; RN - Rank; T2D - Type 2 Diabetes; BD - Bipolar Disorder; CD - Crohn's Disease; HT - Hypertension; T1D - Type 1 Diabetes; CAD - Coronary Artery Disease; RA - Rheumatoid Arthritis.
  2. Description of therapeutic targets and novel therapeutic targets. Total 452 unique therapeutic targets and total 428 unique novel therapeutic targets obtained for seven complex diseas
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BMC Medical Genomics

ISSN: 1755-8794

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