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Table 5 Binary classification of therapeutic targets

From: Identification of novel therapeutics for complex diseases from genome-wide association data

PH Total genes in all search spaces Binary classification
T2D 4,292 TP = 7 FP = 77
   FN = 9 TN = 4,199
T1D 5,339 TP = 2 FP = 95
   FN = 9 TN = 5,233
HT 8,427 TP = 5 FP = 73
   FN = 15 TN = 8,334
RA 4,970 TP = 6 FP = 71
   FN = 9 TN = 4,884
BD 5,667 TP = 1 FP = 58
   FN = 6 TN = 5,602
CD 5,644 TP = 0 FP = 135
   FN = 0 TN = 5,509
CAD 4,715 TP = 4 FP = 98
   FN = 8 TN = 4,605
  1. Abbreviations - TP - True Positives; FP - False Positives; TN - True Negatives; FN - False Negatives; TN - True Negatives; PH - Phenotypes; T2D - Type 2 Diabetes; T1D - Type 1 Diabetes; HT - Hypertension; RA - Rheumatoid Arthritis; CD - Crohn's Disease; CAD - Coronary Artery Disease; BD - Bipolar Disorder.
  2. Binary classification of therapeutic targets considering targets present in six search spaces from weakly significant data set.