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Table 5 Binary classification of therapeutic targets

From: Identification of novel therapeutics for complex diseases from genome-wide association data

PH

Total genes in all search spaces

Binary classification

T2D

4,292

TP = 7

FP = 77

  

FN = 9

TN = 4,199

T1D

5,339

TP = 2

FP = 95

  

FN = 9

TN = 5,233

HT

8,427

TP = 5

FP = 73

  

FN = 15

TN = 8,334

RA

4,970

TP = 6

FP = 71

  

FN = 9

TN = 4,884

BD

5,667

TP = 1

FP = 58

  

FN = 6

TN = 5,602

CD

5,644

TP = 0

FP = 135

  

FN = 0

TN = 5,509

CAD

4,715

TP = 4

FP = 98

  

FN = 8

TN = 4,605

  1. Abbreviations - TP - True Positives; FP - False Positives; TN - True Negatives; FN - False Negatives; TN - True Negatives; PH - Phenotypes; T2D - Type 2 Diabetes; T1D - Type 1 Diabetes; HT - Hypertension; RA - Rheumatoid Arthritis; CD - Crohn's Disease; CAD - Coronary Artery Disease; BD - Bipolar Disorder.
  2. Binary classification of therapeutic targets considering targets present in six search spaces from weakly significant data set.