Table 7 Top 20 pathways for the four thyroid cancer subtypes as extracted from the literature.
From: Molecular profiling of thyroid cancer subtypes using large-scale text mining
Top | PTC | ATC | FTC | MTC | ||||
|---|---|---|---|---|---|---|---|---|
| Â | Pathway | Evidence | Pathway | Evidence | Pathway | Evidence | Pathway | Evidence |
#1 | Apoptosis | 22120515 | Apoptosis | 20067110 | Apoptosis | 24213562 | Apoptosis | 10614665 |
#2 | Cell cycle | 23231932 | Cell cycle | 22688732 | Angiogenesis | 14605010 | Cell cycle | 21973234 |
#3 | MAPK pathway | 23544999 | Angiogenesis | 17575107 | Cell cycle | 19190121 | Angiogenesis | 20133461 |
#4 | Angiogenesis | 23528368 | PI3K/Akt pathway | 22918703 | PI3K/Akt pathway | 18492751 | RET pathway | 15316058 |
#5 | DNA Repair | 21860547 | MAPK pathway | 17989125 | DNA Repair | 22331172 | mTOR pathway | 22136849 |
#6 | S Phase | 22329804 | S Phase | 18813835 | S Phase | 2874658 | S Phase | 18791128 |
#7 | PI3K/Akt pathway | 22744707 | M Phase | 22399519 | MAPK pathway | 18492751 | Focal Adhesion | 12850460 |
#8 | Glucose transport | 21606885 | NF-kB pathway | 19158360 | PI3K pathway | 23128507 | MAPK pathway | 15746253 |
#9 | PI3K pathway | 20804548 | Glucose transport | 12667615 | Focal Adhesion | 20225271 | Hedgehog (Hh) pathway | 23410206 |
#10 | Wnt/beta-catenin pathway | 23261982 | Focal Adhesion | 19293266 | Oxidative Stress | 22331172 | Notch1 pathway | 18520232 |
#11 | TGF-beta pathway | 21874046 | Wnt pathway | 15650354 | TGF-beta pathway | 10942134 | bone remodeling | 6611007 |
#12 | mTOR pathway | 21822208 | Glycolysis | 3155492 | Glucose transport | 16273245 | mRNA Processing | 2582437 |
#13 | Oxidative Stress | 9774495 | Notch1 pathway | 23594881 | thyroid hormone production | N/A | Raf-1 pathway | 17363508 |
#14 | MAPK/ERK pathway | 22426956 | G1 Phase | 9038381 | Glucose metabolism | 19433487 | PI3K pathway | 17188151 |
#15 | MEK/ERK pathway | 20629553 | mTOR pathway | 20689131 | cAMP pathway | N/A | Notch pathway | 20182588 |
#16 | cAMP pathway | 21479404 | Hedgehog (Hh) pathway | 23860623 | thyroid hormone biosynthesis | N/A | ERK activation | 21470995 |
#17 | Focal Adhesion | 22513979 | STAT3 pathway | 22328572 | Cytokinesis | 15886755 | PI3K/Akt pathway | 23934677 |
#18 | Notch pathway | 23544172 | Wnt/beta-catenin pathway | 17218945 | Hedgehog (Hh) pathway | N/A | Glucose transport | 9426419 |
#19 | Glycolysis | 23846818 | p21 pathway | 22918703 | Glycolysis | N/A | EGFR pathway | 22025146 |
#20 | Glucose metabolism | 20473281 | Rb/E2F pathway | 15118916 | VEGF pathway | 18509004 | Glycolysis | 3155492 |