Skip to main content

Table 1 Summary of selected intervention and cohort studies on gene-diet interactions during the past two years

From: Gene-environment interactions and obesity: recent developments and future directions

Author Study design Genetic markers Main findings
Qi et al. 2011[42] Two years, intervention, n=738 IRS rs2943641 IRS1 genetic variants modified effects of dietary carbohydrate on weight loss
Mattei et al. 2012 [43] Two years, intervention, n=591 TCF7L2 rs7903146 Dietary fat intake modified effect of TCF7L2 genotype on changes in BMI, total fat mass, and trunk fat mass
Qi et al. 2012 [44] Two years, intervention, n=737 GIPR rs2287019 Dietary carbohydrate modified GIPR genotype effects on changes in body weight
Xu, et al. 2013 [23] Two years, intervention, n=734 PPM1K rs1440581 Dietary fat modified genetic effects on changes in weight
Alsaleh et al, 2013 [25] One year, intervention, n=367 ADIPOQ rs2241766 A diet high in n-3 polyunsaturated fatty acids modified the effects of rs2241766 on risk of obesity
Knoll et al 2012 [27] One year, intervention, n=453 FAAH rs324420 The FAAH rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents
de Luis et al, 2013 [26] Three months intervention, n=305 FTO rs9939609 Metabolic improvement secondary to weight loss was better in A carriers with a low fat hypocaloric diet
Lai et al 2013 [45] Four weeks intervention, n=88 Visfatin rs4730153 Visfatin rs4730153 homozygous GG Genotype may affect glucose and lipid metabolism in obese children and adolescents by reducing total triglyceride level and increasing insulin sensitivity to exercise
Qi et al 2012 [8] Cohorts (NHS, HPFS, WGHS) BMI-GRS The genetic association with adiposity was stronger among participants with higher intake of sugar-sweetened beverages than among those with lower intake.
Qi et al 2012 [21] Cohorts (NHS, HPFS) BMI-GRS Sedentary lifestyle may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association.
Qi et al 2014 [6] Cohorts (NHS, HPFS, WGHS) BMI-GRS Participants in the highest risk groups for both fried food and GRS had the highest BMI overall. Eating fried food more than four times a week had twice the effect on BMI for those in the highest third of GRS than those in the lowest third.
  1. GRS: genetic risk score, NHS: the Nurses' Health Study, HPFS: the Health Professionals Follow-up Study, WGHS, the Women's Genome Health Study.
  2. The GRS was calculated on the basis of 32 established BMI-associated variants.