Table 1 Summary of selected intervention and cohort studies on gene-diet interactions during the past two years
From: Gene-environment interactions and obesity: recent developments and future directions
Author | Study design | Genetic markers | Main findings |
|---|---|---|---|
Qi et al. 2011[42] | Two years, intervention, n=738 | IRS rs2943641 | IRS1 genetic variants modified effects of dietary carbohydrate on weight loss |
Mattei et al. 2012 [43] | Two years, intervention, n=591 | TCF7L2 rs7903146 | Dietary fat intake modified effect of TCF7L2 genotype on changes in BMI, total fat mass, and trunk fat mass |
Qi et al. 2012 [44] | Two years, intervention, n=737 | GIPR rs2287019 | Dietary carbohydrate modified GIPR genotype effects on changes in body weight |
Xu, et al. 2013 [23] | Two years, intervention, n=734 | PPM1K rs1440581 | Dietary fat modified genetic effects on changes in weight |
Alsaleh et al, 2013 [25] | One year, intervention, n=367 | ADIPOQ rs2241766 | A diet high in n-3 polyunsaturated fatty acids modified the effects of rs2241766 on risk of obesity |
Knoll et al 2012 [27] | One year, intervention, n=453 | FAAH rs324420 | The FAAH rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents |
de Luis et al, 2013 [26] | Three months intervention, n=305 | FTO rs9939609 | Metabolic improvement secondary to weight loss was better in A carriers with a low fat hypocaloric diet |
Lai et al 2013 [45] | Four weeks intervention, n=88 | Visfatin rs4730153 | Visfatin rs4730153 homozygous GG Genotype may affect glucose and lipid metabolism in obese children and adolescents by reducing total triglyceride level and increasing insulin sensitivity to exercise |
Qi et al 2012 [8] | Cohorts (NHS, HPFS, WGHS) | BMI-GRS | The genetic association with adiposity was stronger among participants with higher intake of sugar-sweetened beverages than among those with lower intake. |
Qi et al 2012 [21] | Cohorts (NHS, HPFS) | BMI-GRS | Sedentary lifestyle may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association. |
Qi et al 2014 [6] | Cohorts (NHS, HPFS, WGHS) | BMI-GRS | Participants in the highest risk groups for both fried food and GRS had the highest BMI overall. Eating fried food more than four times a week had twice the effect on BMI for those in the highest third of GRS than those in the lowest third. |