Figure 4

Comparison of the number of the gene marker candidates between non-filtered and full-filtered method in TNF signaling pathway. (A) TNF signaling pathway mapped with non-filtered candidates. With no filtering method, too many genes are shown in the pathway which makes it difficult to find an appropriate gene marker. (B) TNF signaling pathway mapped with candidates filtered by DEG. The number of genes is greatly reduced compared to the non-filtered method. However, difficulty exists in finding significant gene marker as the number of genes are still too many. (C) TNF signaling pathway mapped with fullfiltered candidates. The number of genes was greatly reduced compared to non-filtered or DEG-only filtered candidates while keeping the genes reported by Yagi et al.(2013).