Inferring drug-disease associations based on known protein complexes

BMC Medical Genomics

Table 1 Top diseases and drugs with a large degree in the bipartite drug-disease network

Disease Name	Number of direct neighbors	Sum of weight on edges	Drug ID	Drug name	Number of directed edges	Sum of weight on edges
Mental disorders	51	39.58	DB00098	Antithymocyte globulin	27	19.90
Cystic fibrosis	33	18.56	DB01259	Lapatinib	18	15.07
Primary biliary cirrhosis	30	20.28	DB08916	Afatinib	17	13.79
Attention deficit hyperactivity disorder	26	16.40	DB00054	Abciximab	16	13.49
Anorexia nervosa	25	17.14	DB00775	Tirofiban	15	15.31
Panic disorder	25	16.77	DB00072	Trastuzumab	12	9.13
Sudden infant death syndrome	25	18.27
Epilepsy	24	13.37
Hypertension	24	13.26
Migraine	21	11.10
Supranuclear palsy, progressive	21	11.51
Mucocutaneous lymph node syndrome	11	8.45
Subacute sclerosing panencephalitis	10	5

ISSN: 1755-8794