Inferring drug-disease associations based on known protein complexes

BMC Medical Genomics

Table 3 Drug-hypertension associations (weight ≥ 0.5)

ID	Drug ID	Drug Name	Weight	ID	Drug ID	Drug Name	Weight
1	*DB06216*	*Asenapine*	*0.71*	17	DB00413	Pramipexole	0.52
2	DB00571	Propranolol	0.66	18	DB00589	Lisuride	0.52
3	DB08807	Bopindolol	0.66	19	DB01149	Nefazodone	0.52
4	DB00960	Pindolol	0.64	20	*DB00247*	*Methysergide*	*0.52*
5	DB00866	Alprenolol	0.59	21	DB01049	Ergoloid mesylate	0.52
6	DB01359	Penbutolol	0.59	22	DB00714	Apomorphine	0.52
7	DB01200	Bromocriptine	0.54	23	DB00656	Trazodone	0.51
8	DB00248	Cabergoline	0.54	24	DB01142	Doxepin	0.50
9	DB00246	Ziprasidone	0.53	25	DB00904	Ondansetron	0.50
10	DB00334	Olanzapine	0.53	26	DB08815	Lurasidone	0.50
11	DB01238	Aripiprazole	0.53	27	DB00216	Eletriptan	0.50
12	DB00363	Clozapine	0.53	28	DB00734	Risperidone	0.50
13	DB01224	Quetiapine	0.53	29	*DB00726*	*Trimipramine*	*0.50*
14	DB01186	Pergolide	0.53	30	DB04946	Iloperidone	0.50
15	DB01392	Yohimbine	0.52	31	*DB01267*	*Paliperidone*	*0.50*
16	DB00268	Ropinirole	0.52

Drug ID represents the unique DrugBank accession number of a drug. Drug Name represents the corresponding name of a Drug ID. Weight represents the value of correlation between a drug and the mental disorders. 26 drugs are approved by our benchmark. Among the remaining 5 drugs, 4 (in bold italic) have negative relationships with the mental disorders and 1 (in underlined bold) has a positive relationship with the mental disorders.

ISSN: 1755-8794