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Table 1 A subset of negative-class proteins predicted to be disease-related

From: Network-based prediction and knowledge mining of disease genes

Conf. Score OS DORIF OMIM Suspected Disease Relationship
6.24096 CDH5 - - Melanoma, tumor metastasis
5.8186 PTCH1 - 109400, 605462, 610828 Basal Cell Nevus Syndrome, Basal Cell Carcinoma
5.19721 STAMBPL1 - - Very light evidence, Alzheimer's
5.14813 MDH2 - - Very light evidence, tumor development
1.09972 DPP4 - - Diabetes (17 PMIDs), colon cancer (3 PMIDs)
1.09972 GRK5 - - Very light evidence, heart failure
0.907016 GZMB - - Lymphoma (30 PMIDs), tumors (92 PMIDs)
0.898631 TCF4 - 610954 Pitt-Hopkins Syndrome, various cancer (light evidence)
0.705929 FGR - - Breast cancer (3 PMIDs), prostate cancer (1 PMID)
0.705929 FLT1 - - Cancer, various
0.705929 PECAM1 - - Cancer, various
0.705929 SREBF2 - - Prostate cancer (2 PMIDs)
0.705929 STAT6 - - Prostate cancer (3 PMIDs)
0.705929 TOP1 - - Leukemia, colon and ovarian cancer
0.664823 CD74 - - Very light evidence, lymphoma
  1. A subset of 15 proteins belonging to the non-disease-related class (lacking DORIF annotation) but predicted to be disease-related, sorted by the ADTree-assigned confidence score. Two proteins (PTCH1 and TCF4) have associated OMIM disorders. 9/15 proteins (CDH5, DPP4, GZMB, FGR, FLT1, PECAM1, SREBF2, STAT6, and TOP1) have moderate to strong evidence of disease association, while 4/15 (STAMBPL1, MDH2, GRK5, and CD74) have light evidence linking them to disease. (n PMIDs) indicates the number of PubMed IDs connecting a protein to a particular disease. 'Conf. Score' is the confidence score assigned by the ADTree classifier, 'OS' is the official symbol of the gene, 'DORIF' is Disease Ontology + Gene Reference Into Function, 'OMIM' is the MIM number associated with the gene, 'light evidence' is defined as having a predicted disease association according to the MalaCards database [48]. Disease information for this table was acquired from the GeneCards database [49].