Table 1 Characteristic of the three subject groups on important clinical variables related to cocaine use.
From: Refining multivariate disease phenotypes for high chip heritability
Variable | Group1 250(14.27) | Group2 339(19.35) | Group3 926(52.85) | Group4 237(13.53) |
|---|---|---|---|---|
Tolerance to cocaine | 124(49.60) | 80(23.60) | 807(87.15) | 123(51.90) |
Withdrawal from cocaine | 14(5.60) | 275(81.12) | 813(87.80) | 192(81.01) |
Using cocaine in larger amounts or over longer period than intended | 249(99.60) | 323(95.28) | 816(88.12) | 103(43.46) |
Persistent desiring or unsuccessful cutting down cocaine use | 223(89.20) | 326(96.17) | 839(90.60) | 233(98.31) |
Great amount of time spent in activities related to cocaine | 240(96.00) | 290(85.55) | 823(88.88) | 82(34.60) |
Gave up or reduced important activities because of cocaine use | 170(68.00) | 212(62.54) | 806(87.04) | 156(65.82) |
Cocaine use despite knowledge of problems likely caused by cocaine | 209(83.60) | 315(92.92) | 817(88.23) | 170(71.73) |
Number of CD criteria endorsed | 4.92(1.07) | 5.37(1.08) | 6.18(2.10) | 4.47(1.50) |
Age when first used cocaine | 21.93(6.34) | 22.32(6.51) | 21.44(5.75) | 22.97(8.42) |
Age onset of DSM4 cocaine dependence | 28.24(7.88) | 28.31(7.95) | 26.63(6.70) | 28.32(8.06) |
Transition time in years from first cocaine use to first CD diagnosis | 8.01(12.05) | 8.07(12.91) | 12.15(21.30) | 15.19(24.65) |