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Figure 4 | BMC Medical Genomics

Figure 4

From: Multiple target drug cocktail design for attacking the core network markers of four cancers using ligand-based and structure-based virtual screening methods

Figure 4

Transcription_P53 signaling pathway. It is the second highest scoring map (i.e., the map with the second lowest p-value). The Tumor protein p53, also known as p53 ortransformation-related protein 53 (TRP53), plays a significant role in shielding the genome integrity. While being activated, p53 will bind to the enhancer/promoter regions of downstream target genes. And then it regulates the transcription of these genes, through which it initiates cellular processes that responsible for lots of its tumor-suppressor related functions. It is not surprising that core network of 4 cancers are related to the p53 signaling pathway.

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