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Table 6 the pathway analysis results of Panther.

From: Multiple target drug cocktail design for attacking the core network markers of four cancers using ligand-based and structure-based virtual screening methods

Rank

Pathway title

Count

Gene

1

p53 pathway

8

EP300,CREBBP,HDAC1,HDA2,TRAF2,CDK2,MDM2,TP53

2

Wnt signaling pathway

7

EP300,CREBBP,HDAC1,MYC,HDAC2,CTNN1,TP53

3

p53 pathway feedback loops 2

6

MYC,RB1,CTNNB1,CDK2,MDM2,TP53

4

Parkinson disease

4

YWHAZ, CUL1,PSMA3,SRC

4

Gonadotropin releasing hormone receptor pathway

4

EP300,CREBBP,CTNNB1, SRC

5

Huntington disease

3

EP300,CREBBP,TP53

6

Apoptosis signaling pathway

2

TRAF2,TP53

6

Angiogenesis

2

CTNNB1, SRC

6

P53 pathway feedback loops 1

2

MDM2, TP53

6

Cadherin signaling pathway

2

CTNNB1, SRC

6

Transcription regulation by bZIP transcription factor

2

EP300, CREBBP

6

TGF-beta signaling pathway

2

EP300, CREBBP

7

Interleukin signaling pathway

1

MYC

7

Alzheimer disease-presenilin pathway

1

CTNNB1

7

Integrin signalling pathway

1

SRC

7

Insulin/IGF pathway-protein kinase B signaling cascade

1

MDM2

7

Hypoxia response via HIF activation

1

CREBBP

7

Ubiquitin proteasome pathway

1

MDM2

7

p53 pathway by glucose deprivation

1

TP53

  1. Please see their statistical distribution in Figure 2.