Skip to main content

Advertisement

Table 6 the pathway analysis results of Panther.

From: Multiple target drug cocktail design for attacking the core network markers of four cancers using ligand-based and structure-based virtual screening methods

Rank Pathway title Count Gene
1 p53 pathway 8 EP300,CREBBP,HDAC1,HDA2,TRAF2,CDK2,MDM2,TP53
2 Wnt signaling pathway 7 EP300,CREBBP,HDAC1,MYC,HDAC2,CTNN1,TP53
3 p53 pathway feedback loops 2 6 MYC,RB1,CTNNB1,CDK2,MDM2,TP53
4 Parkinson disease 4 YWHAZ, CUL1,PSMA3,SRC
4 Gonadotropin releasing hormone receptor pathway 4 EP300,CREBBP,CTNNB1, SRC
5 Huntington disease 3 EP300,CREBBP,TP53
6 Apoptosis signaling pathway 2 TRAF2,TP53
6 Angiogenesis 2 CTNNB1, SRC
6 P53 pathway feedback loops 1 2 MDM2, TP53
6 Cadherin signaling pathway 2 CTNNB1, SRC
6 Transcription regulation by bZIP transcription factor 2 EP300, CREBBP
6 TGF-beta signaling pathway 2 EP300, CREBBP
7 Interleukin signaling pathway 1 MYC
7 Alzheimer disease-presenilin pathway 1 CTNNB1
7 Integrin signalling pathway 1 SRC
7 Insulin/IGF pathway-protein kinase B signaling cascade 1 MDM2
7 Hypoxia response via HIF activation 1 CREBBP
7 Ubiquitin proteasome pathway 1 MDM2
7 p53 pathway by glucose deprivation 1 TP53
  1. Please see their statistical distribution in Figure 2.