Figure 2

The B-cell epitope and surrounding area recognized by neutralizing antibody AR3C. (A) The heavy and light chains of mAb AR3C are shown in red and yellow respectively and the E2 chain in light blue; (B) The B-cell epitope on E2c is highlighted in pink (4MWF, chain C: 422, 427, 428, 429, 430, 431, 432, 433, 436, 438, 439, 441, 442, 443, 446, 503 and 529), and the ring area surrounding B-cell epitope is green (4MWF, chain C: 434, 435, 437, 440, 444, 528, 531 and 613); (C) The variable residues which are different from mAb AR3C-neutralized are highlighted in yellow (4MWF, chain C: 422, 430, 431, 432, 433, 438 and 442).