Skip to main content

Table 1 Discontinuous motifs on B-cell epitope and its surrounding area.

From: A systematic analysis of a broadly neutralizing antibody AR3C epitopes on Hepatitis C virus E2 envelope glycoprotein and their cross-reactivity

Isolate

Geno-type

IC50 (µg/ml)a

Genbank accession no.

Discontinuous motif

    

B-cell epitope

Surrounding area

4mwfC

   

ILNCNESLGLALFYKCW

NTWGQSAY

H77

1a

1

AF009606.1

ILNCNESLGLALFYKCW

NTWGQSAY

H

 

1

M67463.1

ILNCNESLGLALFYKCW

NTWGQSAY

OH8

1b

5

AY545951.1

ILNCNDSLGLALFYRCW

QTFAANDY

UKN1 B12.16

 

1

AY734974.1

ILNCNDSLGLALFYNCW

NTFAVTEY

JFH-1

2a

1

AB047639.1

ILNCNDSLGLALFYRCW

NTFATTEY

J6

 

10

AF177036.1

ILNCNDSLGIALFYSCW

HTFSTTEY

UKN2 A1.2

 

10

AY734977.1

ILNCNDSLGIALFYSCW

QTFSTTEY

UNK2 B1.1

2b

10

AY734982.1

ILNCNDSLGLALFYNCW

QTFSVSEY

UKN4 21.16

4

1

AY734987.2

ILNCNDSLGLALFYSCW

NTFGHNEY

UKN5 15.7

5

1

EF427672.1

ILNCQDSLGIALLYKCW

QTFGFNSY

  1. a Neutralization activity of E2-specific neutralizing antibody AR3C (IC50 data are from reference [18]).
  2. Comparing the discontinuous motifs on B-cell epitope, residues differing from the consensus are underlined, and the highly variable position lacking a consensus residue is underlined and in italics.