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Table 1 Discontinuous motifs on B-cell epitope and its surrounding area.

From: A systematic analysis of a broadly neutralizing antibody AR3C epitopes on Hepatitis C virus E2 envelope glycoprotein and their cross-reactivity

Isolate Geno-type IC50 (µg/ml)a Genbank accession no. Discontinuous motif
     B-cell epitope Surrounding area
4mwfC     ILNCNESLGLALFYKCW NTWGQSAY
H77 1a 1 AF009606.1 ILNCNESLGLALFYKCW NTWGQSAY
H   1 M67463.1 ILNCNESLGLALFYKCW NTWGQSAY
OH8 1b 5 AY545951.1 ILNCNDSLGLALFYRCW QTFAANDY
UKN1 B12.16   1 AY734974.1 ILNCNDSLGLALFYNCW NTFAVTEY
JFH-1 2a 1 AB047639.1 ILNCNDSLGLALFYRCW NTFATTEY
J6   10 AF177036.1 ILNCNDSLGIALFYSCW HTFSTTEY
UKN2 A1.2   10 AY734977.1 ILNCNDSLGIALFYSCW QTFSTTEY
UNK2 B1.1 2b 10 AY734982.1 ILNCNDSLGLALFYNCW QTFSVSEY
UKN4 21.16 4 1 AY734987.2 ILNCNDSLGLALFYSCW NTFGHNEY
UKN5 15.7 5 1 EF427672.1 ILNCQDSLGIALLYKCW QTFGFNSY
  1. a Neutralization activity of E2-specific neutralizing antibody AR3C (IC50 data are from reference [18]).
  2. Comparing the discontinuous motifs on B-cell epitope, residues differing from the consensus are underlined, and the highly variable position lacking a consensus residue is underlined and in italics.
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