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Table 2 Top ranked discontinuous peptides in the E2 protein dataset.

From: A systematic analysis of a broadly neutralizing antibody AR3C epitopes on Hepatitis C virus E2 envelope glycoprotein and their cross-reactivity

Rank Discontinuous peptides Frequency Accumulative percentage Validation status
1 ILNCNDSLGIALFYKCW 754 14.12% Missing
2 ILNCNDSLGLALFYKCW 320 20.11% Missing
3 ILNCNASLGIALFYKCW 256 24.91% Missing
4 ILNCNDSLGLALFYRCW 240 29.40% Neutralized
5 ILNCNASLGVALFYKCW 237 33.84% Missing
6 ILNCNESLGLALFYKCW 221 37.98% Neutralized
7 ILNCNDSLGIALIYKCW 213 41.97% Missing
8 ILNCNASLGLALFYRCW 209 45.88% Missing
9 ILNCNESIGIALFYKCW 173 49.12% Missing
10 ILNCNDSLGIALFYRCW 152 51.97% Missing
11 ILNCNDSLGLALFYNCW 141 54.61% Neutralized
12 ILNCNDSLGLALFYSCW 127 56.99% Neutralized
13 ILNCNDTIGIALFYRCW 127 59.36% Missing
14 ILNCNDSIGIALFYRCW 123 61.67% Missing
15 ILNCNDSLGIALLYKCW 102 63.58% Missing
16 VLNCNESIGLALFYKCW 92 65.30% Missing
17 ILNCNDSLGVALFYKCW 85 66.89% Missing
18 ILNCNASLGLALFYKCW 85 68.48% Missing
19 ILNCNASLGVALLYKCW 80 69.98% Missing
20 ILNCNDSLGIALFYNCW 72 71.33% Missing
21 ILNCDESIGIALFYKCW 71 72.66% Missing
22 ILNCNDSIGIALFYKCW 71 73.99% Missing
23 ILNCNESIGLALFYKCW 66 75.22% Missing
24 ILNCNDSLGVALLYKCW 63 76.40% Missing
25 LLNCNDSLGLALFYKCW 55 77.43% Missing
26 ILNCNDSLGIALFYSCW 48 78.33% Neutralized
  1. The top 26 most frequent (including discontinuous peptides identical to discontinuous neutralized motifs) among 402 different patterns of discontinuous peptides are listed. This table lists discontinuous peptide, their frequencies, accumulative frequency and neutralization validation status to mAb AR3C. The neutralized discontinuous motifs are underlined. The residues in italics and underlined, indicate the amino acids that are not presented in the specific position from these known neutralized discontinuous motifs (see Figure 1(c)).
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