Visualization of hub genes in network modules. (A - F) The 50 most connected genes (nodes) and the 500 strongest gene-gene interactions (edges) in each module are shown. The width and the color saturation of the lines (edges) correspond to the weight of the interactions. The orange highlighted nodes correspond to genes that were also statistically significantly dysregulated . Hub genes have a high gene significance value, as well as high eigengene based connectivity (kME). The correlation of both is shown in Additional file 1. (A) and (B) show hub genes from two cerebellum modules. (C) and (D) show hub genes from two frontal cortex BA4 region modules. (E) and (F) show hub genes from two caudate nucleus modules. The remaining hub genes for the other modules of the three networks are shown in Additional files 2, 3 and 4.