Figure 4

Network comparisons between different tissues in HD reveal a high number of similarly correlated genes, as well as common hub genes in all three brain regions. Venn diagrams show the overlap of networks (A) or hub genes (B to F) in the respective modules. Only modules with an overlap of more than 5 hub genes (10%) with modules from other tissues are shown. (A) Venn diagrams highlight the overlap of positively or negatively correlated genes in the networks of the three tissues. All positively, or negatively correlated genes of the significantly correlated modules (Figure 1) for each network were combined and compared to their respective assignment in the other networks. The intersections show the number of genes that were assigned to modules with the same sign of correlation. Caudate nucleus modules CNpos1 (B), CNpos2 (C) and CNpos6 (D) are positively correlated with HD and have common hub genes with cerebellum and frontal cortex BA4 modules. Caudate nucleus module CNneg2 (E) is negatively correlated with HD and also shares common hub genes with cerebellum and frontal cortex BA4 modules. The positively correlated frontal cortex BA4 region module FC4pos4 (F) overlaps with cerebellum, but not caudate nucleus modules.