Figure 5
From: A common gene expression signature in Huntington’s disease patient brain regions
Preservation analysis of HD caudate nucleus network modules in other diseases and in HD mouse models highlights common transcriptional changes. (A) Preservation analysis of HD caudate nucleus network modules in various diseases. The Z-summary values are shown as a heat map from white (-1) to brown (75). Colors next to the modules indicate correlation (cor) with HD, as shown in (B), together with a short summary table of Table 3. HD-II = Huntington’s disease dataset 2; AD = Alzheimer’s disease; ALS = Amyotrophic lateral sclerosis; MS = multiple sclerosis; PD = Parkinson’s disease; SCHIZ = Schizophrenia; RCC = renal cell carcinoma; GG = ganglioglioma; DM1, DM2 = myotonic dystrophy type 1, type 2; DMD = Duchenne Muscular Dystrophy; DCM = dilated cardiomyopathy. For details of the datasets see Table 5. (C and D) A HD caudate nucleus network with only control samples as the input for the preservation analysis was generated (n = 32). (C) Preservation analysis of these human caudate modules in a dataset of only wild type mouse samples from the R6/2 dataset (n = 9), or all wild type mouse samples, respectively (n = 22) (excluding the Q80 data, due to the different type of microarray). (D) The median Z-summary values from the analysis in (C) for modules of certain size ranges were calculated and are shown as a heat map from white (-1) to brown (15). (E) Preservation analysis of HD caudate nucleus network modules in HD mouse models. The Z-summary values are shown as a heat map from white (-1) to brown (15). Colors next to the modules indicate correlation with HD, as shown in (B). Q80 = Hdh480Q; Q92 = Hdh Q92; Q150 = HdhQ150; mth = months.