Table 1 Gene ontology enrichment for the cerebellum network
From: A common gene expression signature in Huntington’s disease patient brain regions
Module | cor | GO-term (DAVID) | Potential regulators |
|---|---|---|---|
CBpos1 | up | metal binding/zinc-finger (0.84, 0.89) | MYOD (0.0314)2, ZIC2 (0.0314)2, E2F1/E2F4 together with DP1/DP2, or RB (0.0314)2, NFY (0.0314)2 |
CBpos2 | up | DNA binding/zinc-finger (3.97, 0.003) | miR124 (0.054)1 |
chromatin binding/remodeling (1.82, 0.096) | |||
CBpos3 | up | ubiquitin protein ligase binding (1.1, 0.49) | |
CBpos4 | up | metal binding/zinc-finger (6.98, 0.000) | |
chromatin modification (4.8, 0.004) | |||
RNA binding/processing (3.41, 0.03) | |||
CBpos5 | up | protein folding/chaperones (6.77, 0.000) | HSF1 (0.09)1 |
chromatin assembly (3.19, 0.003) | HSF1 (0.000)2, NRF1 (0.001)2, USF1 (0.001)2, E4BP4 (0.024)2 | ||
mRNA processing (2.95, 0.034) | |||
CBpos6 | up | metallothionein (4.24, 0.003) | miR124 (0.027)1, let7 (0.027)1, SOX2 (0.027)1, MYOG (0.027)1, HSF1 (0.044)1 |
CBneg1 | down | synapse (2.14, 0.33) | |
CBneg2 | down | mitochondrion (10.44, 0.000) | NRF1 (0.108)1 |
proteasome (3.13, 0.000) | E4F1 (0.000)2, PAX3 (0.006)2, ATF (0.007)2, ELK1 (0.012)2 | ||
CBneg3 | down | mitochondrion (2.77, 0.007) | SF1 (0.000)2, ERR1 (0.001)2, PAX4 (0.001)2, TCF3 (0.002)2, ZBTB14 (0.046)2 |
CBneg4 | down | mitochondrion (2.85, 0.005) | |
CBneg5 | down | endoplasmic reticulum (1.02, 0.95) | |
CBneg6 | down | cytoplasmic vesicle (0.88, 0.99) | |
HTT | down | mitochondrion (5.3, 0.000) |