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Table 1 Gene ontology enrichment for the cerebellum network

From: A common gene expression signature in Huntington’s disease patient brain regions

Module cor GO-term (DAVID) Potential regulators
CBpos1 up metal binding/zinc-finger (0.84, 0.89) MYOD (0.0314)2, ZIC2 (0.0314)2, E2F1/E2F4 together with DP1/DP2, or RB (0.0314)2, NFY (0.0314)2
CBpos2 up DNA binding/zinc-finger (3.97, 0.003) miR124 (0.054)1
chromatin binding/remodeling (1.82, 0.096)
CBpos3 up ubiquitin protein ligase binding (1.1, 0.49)  
CBpos4 up metal binding/zinc-finger (6.98, 0.000)  
chromatin modification (4.8, 0.004)
RNA binding/processing (3.41, 0.03)
CBpos5 up protein folding/chaperones (6.77, 0.000) HSF1 (0.09)1
chromatin assembly (3.19, 0.003) HSF1 (0.000)2, NRF1 (0.001)2, USF1 (0.001)2, E4BP4 (0.024)2
mRNA processing (2.95, 0.034)
CBpos6 up metallothionein (4.24, 0.003) miR124 (0.027)1, let7 (0.027)1, SOX2 (0.027)1, MYOG (0.027)1, HSF1 (0.044)1
CBneg1 down synapse (2.14, 0.33)  
CBneg2 down mitochondrion (10.44, 0.000) NRF1 (0.108)1
proteasome (3.13, 0.000) E4F1 (0.000)2, PAX3 (0.006)2, ATF (0.007)2, ELK1 (0.012)2
CBneg3 down mitochondrion (2.77, 0.007) SF1 (0.000)2, ERR1 (0.001)2, PAX4 (0.001)2, TCF3 (0.002)2, ZBTB14 (0.046)2
CBneg4 down mitochondrion (2.85, 0.005)  
CBneg5 down endoplasmic reticulum (1.02, 0.95)  
CBneg6 down cytoplasmic vesicle (0.88, 0.99)  
HTT down mitochondrion (5.3, 0.000)  
  1. Gene ontology (GO) enrichment for the HD cerebellum network. Genes in the identified modules were analyzed using DAVID. The sign of the correlation (cor) with HD and the over-represented GO-terms are shown. The first number in brackets after the GO-term is the respective fold enrichment, the second number the adjusted P-value, as determined by DAVID. All significantly enriched (adjusted P <0.05) GO-terms are shown. In cases where no significantly enriched GO-term was identified, the GO-term with the highest fold enrichment is shown. Potential regulators of a module were identified using 1GO-Elite, or 2WebGestalt. Adjusted P-values are given in brackets after the name. Regulators that were identified by both tools are highlighted in bold. HTT is part of the CBneg2 module in the cerebellum network. The GO-term enrichment for 100 genes with the highest correlation with HTT is shown.