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Table 2 Gene ontology enrichment for the frontal cortex (BA4 region) network

From: A common gene expression signature in Huntington’s disease patient brain regions

Module cor GO-term (DAVID) Potential regulators
FC4pos1 up inflammatory response (6.64, 0.000) MEF2 (0.041)1, NFkB (0.041)1, miR34 (0.050)1, let7 (0.041)1
metallothionein (4.02, 0.04) STAT3 (0.005)2, STAT5B (0.005)2, JUN (0.040)2
regulation of transcription (3.58, 0.018)
regulation of apoptosis (3.25, 0.02)
vasculature development (2.7, 0.021)
cation homeostasis (2.68, 0.014)
IκB/NFκB (2.65, 0.02)
FC4pos2 up RNA binding/splicing (2.36, 0.037) E2F (0.006)2, TLX2 (0.006)2, XBP1 (0.008)2, YY1 (0.011)2, HSF1 (0.021)2, LEF1 (0.021)2, MYC (0.021)2, SOX5 (0.025)2, AR (0.031)2
FC4pos3 up amino acid catabolic process (5.52, 0.005) miR155 (0.018)1
fatty acid metabolism (3.25, 0.011) MEF2 (0.038)2
FC4pos4 up protein folding/chaperones (3.75, 0.001) miR1 (0.009)1, HSF1 (0.009)1
HSF1 (0.000)2, NFIL3 (0.033)2, STAT1 (0.037)2, SF1 (0.037)2, NFY (0.039)2
FC4neg1 down protein transport (2.07, 0.03) EVI1 (0.011)2, E4F1 (0.045)2, XBP1 (0.045)2, ATF2 (0.045)2
FC4neg2 down membrane proteins (1.49, 0.2)  
FC4neg3 down fibronectin (1.6, 0.84)  
FC4neg4 down zinc-finger (1.74, 0.84)  
mitochondrion (6.01, 0.000)  
proteasome/ubiquitin system (5.01, 0.000) NRF1 (0.036)1
FC4neg5 down glycolysis (3.5, 0.001) ELK1 (0.000)2, SP1 (0.000)2, SF1 (0.001)2, E4F1 (0.001)2, TCF11 (0.005)2, ATF (0.007)2, JUN (0.007)2, NRF1 (0.007)2, CREB (0.028)2
protein folding/chaperones (3.04, 0.015)
protein transport (3.0, 0.002)
HTT n.a. cytoskeleton (1.43, 0.18)  
  1. Gene ontology (GO) enrichment for the frontal cortex BA4 region network. Genes in the identified modules were analyzed using DAVID. The sign of the correlation (cor) with HD and the over-represented GO-terms are shown. The first number in brackets after the GO-term is the respective fold enrichment, the second number the adjusted P-value, as determined by DAVID. All significantly enriched (adjusted P <0.05) GO-terms are shown. In cases where no significantly enriched GO-term was identified, the GO-term with the highest fold enrichment is shown. Potential regulators of a module were identified using 1GO-Elite, or 2WebGestalt. Adjusted P-values are given in brackets after the name. Regulators that were identified by both tools are highlighted in bold. HTT is part of a module, which is not correlated with HD in the frontal cortex BA4 region network. The GO-term enrichment for 100 genes with the highest correlation with HTT is shown. The GO-term enrichment for the frontal cortex network with BA4 and BA9 regions combined is shown in Additional file 11.