Table 2 Gene ontology enrichment for the frontal cortex (BA4 region) network
From: A common gene expression signature in Huntington’s disease patient brain regions
Module | cor | GO-term (DAVID) | Potential regulators |
|---|---|---|---|
FC4pos1 | up | inflammatory response (6.64, 0.000) | MEF2 (0.041)1, NFkB (0.041)1, miR34 (0.050)1, let7 (0.041)1 |
metallothionein (4.02, 0.04) | STAT3 (0.005)2, STAT5B (0.005)2, JUN (0.040)2 | ||
regulation of transcription (3.58, 0.018) | |||
regulation of apoptosis (3.25, 0.02) | |||
vasculature development (2.7, 0.021) | |||
cation homeostasis (2.68, 0.014) | |||
IκB/NFκB (2.65, 0.02) | |||
FC4pos2 | up | RNA binding/splicing (2.36, 0.037) | E2F (0.006)2, TLX2 (0.006)2, XBP1 (0.008)2, YY1 (0.011)2, HSF1 (0.021)2, LEF1 (0.021)2, MYC (0.021)2, SOX5 (0.025)2, AR (0.031)2 |
FC4pos3 | up | amino acid catabolic process (5.52, 0.005) | miR155 (0.018)1 |
fatty acid metabolism (3.25, 0.011) | MEF2 (0.038)2 | ||
FC4pos4 | up | protein folding/chaperones (3.75, 0.001) | miR1 (0.009)1, HSF1 (0.009)1 |
HSF1 (0.000)2, NFIL3 (0.033)2, STAT1 (0.037)2, SF1 (0.037)2, NFY (0.039)2 | |||
FC4neg1 | down | protein transport (2.07, 0.03) | EVI1 (0.011)2, E4F1 (0.045)2, XBP1 (0.045)2, ATF2 (0.045)2 |
FC4neg2 | down | membrane proteins (1.49, 0.2) | |
FC4neg3 | down | fibronectin (1.6, 0.84) | |
FC4neg4 | down | zinc-finger (1.74, 0.84) | |
mitochondrion (6.01, 0.000) | |||
proteasome/ubiquitin system (5.01, 0.000) | NRF1 (0.036)1 | ||
FC4neg5 | down | glycolysis (3.5, 0.001) | ELK1 (0.000)2, SP1 (0.000)2, SF1 (0.001)2, E4F1 (0.001)2, TCF11 (0.005)2, ATF (0.007)2, JUN (0.007)2, NRF1 (0.007)2, CREB (0.028)2 |
protein folding/chaperones (3.04, 0.015) | |||
protein transport (3.0, 0.002) | |||
HTT | n.a. | cytoskeleton (1.43, 0.18) |