Table 4 Gene ontology enrichment for conserved genes between HD networks
From: A common gene expression signature in Huntington’s disease patient brain regions
Overlap | GO-term (DAVID) | Potential regulators |
|---|---|---|
Positively correlated genes | ||
CN and FC-BA4 | inflammatory response (5.6, 0.001) | MYC/MAX (0.010)2, STAT3 (0.010)2, ETS2 (0.020)2 |
epithelial to mesenchymal transition (1.18, 0.026) | ||
CN and CB | regulation of transcription (5.2, 0.000) | |
mRNA processing (3.69, 0.001) | ||
apical junction complex (1.91, 0.027) | ||
FC-BA4 and CB | zinc-finger (1.17, 0.44) | |
all three networks | metallothionein (5.1, 0.000) | FOXF2 (0.002)2, NFIL3 (0.010)2, LEF1 (0.017)2, HSF1 (0.017)2, ATF2 (0.022)2, HIF1A (0.026)2, SP1 (0.042)2 |
stress response/chaperones (2.62, 0.02) | ||
angiogenesis (2.61, 0.039) | ||
Negatively correlated genes | ||
CN and FC-BA4 | synaptic transmission (4.8, 0.000) | REST (0.004)2, EGR4 (0.015)2, SP1 (0.015)2, ATF1 (0.022)2, MEIS1 (0.022)2, ELK1 (0.022)2, ESRRA (0.040)2, ATF3 (0.046)2, E4F (0.046)2, SF1 (0.046)2, LEF1 (0.046)2 |
ion channels (4.65, 0.000) | ||
protein catabolic process (4.23, 0.008) | ||
CN and CB | mitochondrion (8.46, 0.000) | SF1 (0.002)2, E4F (0.020)2 |
intracellular protein transport (3.02, 0.023) | ||
vesicle mediated transport (2.19, 0.013) | ||
FC-BA4 and CB | coenzyme metabolic process (1.86, 0.98) | ELK1 (0.007)2, E4F (0.007)2 |
all three networks | mitochondrion (6.01, 0.000) | CREB (0.000)2, ATF3 (0.001)2, SF1 (0.015)2, ERR1 (0.015)2, TCF11 (0.015)2, ELK1 (0.018)2, ATF4 (0.018)2, SREBF1 (0.018)2, ATF6 (0.019)2, E4F (0.024)2, JUN (0.026)2, EGR1 (0.039)2, NRF1 (0.049)2 |
glycolysis (2.74, 0.003) | ||
intracellular protein transport (2.59, 0.028) | ||
proteasome (1.97, 0.001) | ||
synaptic vesicle (1.82, 0.018) | ||