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Table 7 Gene ontology enrichment for the consensus networks in mouse datasets

From: A common gene expression signature in Huntington’s disease patient brain regions

Module cor GO-term (DAVID) Transcription factor
Hdh Q150
Q150pos1 up extracellular matrix (1.71, 0.65)  
Q150neg1 down synaptic transmission/synapse (8.81, 0.000) CREB (0.045)1
neuron projection/axon (2.4, 0.019)
mitochondrion (2.1, 0.007)
R6/2pos1 up fatty acid metabolism (1.98, 0.13) SOX9 (0.049)2
R6/2neg1 down synaptic transmission (6.77, 0.000)
gated channel activity (2.3, 0.02)
neurotransmitter transport (2.08, 0.005)
R6/2neg2 down ion transport (1.68, 0.64)
  1. Gene ontology (GO) enrichment for the consensus network analysis of the HD caudate nucleus dataset with HD mouse models. Genes in the identified modules were analyzed using DAVID. The sign of the correlation (cor) and the over-represented GO-terms are shown. The first number in brackets after the GO-term is the respective fold enrichment, the second number the adjusted P-value, as determined by DAVID. All significantly enriched (adjusted P <0.05) GO-terms are shown. In cases where no significantly enriched GO-term was identified, the GO-term with the highest fold enrichment is shown. Potential regulators of a module were identified using 1GO-Elite, or 2WebGestalt. Adjusted P-values are given in brackets after the name.