A common gene expression signature in Huntington’s disease patient brain regions

BMC Medical Genomics

Table 7 Gene ontology enrichment for the consensus networks in mouse datasets

Module	cor	GO-term (DAVID)	Transcription factor
*Hdh* Q150
Q150pos1	up	extracellular matrix (1.71, 0.65)
Q150neg1	down	synaptic transmission/synapse (8.81, 0.000)	CREB (0.045)¹
		neuron projection/axon (2.4, 0.019)
		mitochondrion (2.1, 0.007)
R6/2
R6/2pos1	up	fatty acid metabolism (1.98, 0.13)	SOX9 (0.049)²
R6/2neg1	down	synaptic transmission (6.77, 0.000)
		gated channel activity (2.3, 0.02)
		neurotransmitter transport (2.08, 0.005)
R6/2neg2	down	ion transport (1.68, 0.64)

Gene ontology (GO) enrichment for the consensus network analysis of the HD caudate nucleus dataset with HD mouse models. Genes in the identified modules were analyzed using DAVID. The sign of the correlation (cor) and the over-represented GO-terms are shown. The first number in brackets after the GO-term is the respective fold enrichment, the second number the adjusted P-value, as determined by DAVID. All significantly enriched (adjusted P <0.05) GO-terms are shown. In cases where no significantly enriched GO-term was identified, the GO-term with the highest fold enrichment is shown. Potential regulators of a module were identified using ¹GO-Elite, or ²WebGestalt. Adjusted P-values are given in brackets after the name.

ISSN: 1755-8794