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Table 2 Genomic segments significantly over- or under-expressed

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. non-DS AMKL

Chr and location a

Segment start b

Segment end b

'A'/'B' ratio

q-value

Genes in the segment c

Over-expressed segments

chr15 15q21.2

50,250,001

50,750,000

3.27

0.00233

ATP8B4- SLC27A2+ HDC+ GABPB1+ FLJ10038+ GABPB1-AS1+ Hs.656448+ Hs.660869+ d USP8+

chr4 4q31.1

144,750,001

145,250,000

2.21

0.00024

GYPE+ Hs.658686- GYPB + GYPA +

chr19 19q13.2

45,000,001

45,500,000

1.58

0.00461

ZNF180- PVR+ CEACAM19- BCL3+ CBLC+ BCAM+ PVRL2- Hs.666142- TOMM40+ APOE+ APOC1 + APOC4+ APOC2 + CLPTM1+

b) DS AMKL vs. MK

Chr and location

Segment start

Segment end

'A'/'D' ratio

q-value

Genes in the segment

Over-expressed segments

     

chr3 p26.2

3,500,001

4,000,000

20.81

0.00006

Hs.241414+ Hs.587205+ LRRN1 + Hs.128128+

chr1 1q23

166,000,001

166,500,000

18.07

0.00004

Hs.22930+ FAM78B+ Hs.662048+

chr15 15q26.2

96,750,001

97,250,000

14.73

0.00001

Hs.677040+ Hs.661950+ NR2F2-AS1 + NR2F2- Hs.592015+

Under-expressed segments

chr4 4q12-q21

74,750,001

75,250,000

0.45

0.00079

PF4 - PPBP - CXCL5- CXCL3 - CXCL2- MTHFD2L- Hs.662627- EREG-

chr4 4q32.1

156,250,001

156,750,000

0.13

0.00012

MAP9- GUCY1A3 - Hs.612374- GUCY1B3 -

c) Non-DS AMKL vs. MK

Chr and location

Segment start

Segment end

'B'/'D' ratio

q-value

Genes in the segment

Over-expressed segments

chr15 15q26.2

96,750,001

97,250,000

22.30

<0.00001

Hs.677040+ Hs.661950+ NR2F2-AS1 + NR2F2- Hs.592015+

Under-expressed segments

chr4 4q13-q21

74,500,001

75,000,000

0.39

0.00009

IL8- CXCL6- PF4V1 - CXCL1- PF4 - PPBP - CXCL5- CXCL3 - CXCL2-

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BMC Medical Genomics

ISSN: 1755-8794

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