Skip to main content

Advertisement

Table 2 Genomic segments significantly over- or under-expressed

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. non-DS AMKL
Chr and location a Segment start b Segment end b 'A'/'B' ratio q-value Genes in the segment c
Over-expressed segments
chr15 15q21.2 50,250,001 50,750,000 3.27 0.00233 ATP8B4- SLC27A2+ HDC+ GABPB1+ FLJ10038+ GABPB1-AS1+ Hs.656448+ Hs.660869+ d USP8+
chr4 4q31.1 144,750,001 145,250,000 2.21 0.00024 GYPE+ Hs.658686- GYPB + GYPA +
chr19 19q13.2 45,000,001 45,500,000 1.58 0.00461 ZNF180- PVR+ CEACAM19- BCL3+ CBLC+ BCAM+ PVRL2- Hs.666142- TOMM40+ APOE+ APOC1 + APOC4+ APOC2 + CLPTM1+
b) DS AMKL vs. MK
Chr and location Segment start Segment end 'A'/'D' ratio q-value Genes in the segment
Over-expressed segments      
chr3 p26.2 3,500,001 4,000,000 20.81 0.00006 Hs.241414+ Hs.587205+ LRRN1 + Hs.128128+
chr1 1q23 166,000,001 166,500,000 18.07 0.00004 Hs.22930+ FAM78B+ Hs.662048+
chr15 15q26.2 96,750,001 97,250,000 14.73 0.00001 Hs.677040+ Hs.661950+ NR2F2-AS1 + NR2F2- Hs.592015+
Under-expressed segments
chr4 4q12-q21 74,750,001 75,250,000 0.45 0.00079 PF4 - PPBP - CXCL5- CXCL3 - CXCL2- MTHFD2L- Hs.662627- EREG-
chr4 4q32.1 156,250,001 156,750,000 0.13 0.00012 MAP9- GUCY1A3 - Hs.612374- GUCY1B3 -
c) Non-DS AMKL vs. MK
Chr and location Segment start Segment end 'B'/'D' ratio q-value Genes in the segment
Over-expressed segments
chr15 15q26.2 96,750,001 97,250,000 22.30 <0.00001 Hs.677040+ Hs.661950+ NR2F2-AS1 + NR2F2- Hs.592015+
Under-expressed segments
chr4 4q13-q21 74,500,001 75,000,000 0.39 0.00009 IL8- CXCL6- PF4V1 - CXCL1- PF4 - PPBP - CXCL5- CXCL3 - CXCL2-