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Table 3 List of the five most over- or under-expressed genes (all significantly, with q < 0.05)

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. non-DS AMKL
Gene Value 'A' Value 'B' 'A'/'B' ratio Location Data points SD SD
'A' 'B' 'A' 'B'
Over-expressed genes        
SLITRK6 465.5 19.5 23.860 13q31.1 27 21 113.0 79.6
HDC 1,119.4 65.5 17.097 15q21-q22 36 45 98.8 249.4
ZNF587B 615.0 39.3 15.643 19q13.43a 43 40 427.6 32.2
SOSTDC1 111.7 8.6 12.957 7p21.1 43 45 176.5 108.4
LOC100287628* 1,381.3 107.7 12.820 16p13.2 9 7 80.2 56.8
Under-expressed genes        
Hs.587427* 19.8 407.8 0.049 7p15.2 18 14 28.9 353.3
SPINK2 13.1 285.1 0.046 4q12 36 45 81.8 115.0
Hs.602709* 15.8 370.2 0.043 11q13.2a 9 7 33.1 256.9
RPS12 20.7 519.1 0.040 6q23.2 43 50 113.7 213.0
Hs.355689* 3.7 624.4 0.006 18q11.2a 9 7 47.3 168.4
b) DS AMKL vs. MK         
Gene Value 'A' Value 'D' 'A'/'D' ratio Location Data points SD SD
'A' 'D' 'A' 'D'
Over-expressed genes        
TMEM241 1,036.6 17.6 58.885 18q11.2 18 8 57.7 115.8
CMBL 592.4 11.7 50.759 5p15.2 27 8 142.0 30.1
IFI27 467.8 11.6 40.474 14q32 36 82 90.0 27.6
CSRNP1 640.6 16.8 38.023 3p22 9 8 41.3 138.3
PTGS2 2,205.0 59.2 37.276 1q25.2 q25.3 63 20 156.4 131.6
APOC2* b 431.7 11.7 37.044 19q13.2 54 28 81.4 41.6
SLITRK6 b 465.5 13.3 35.057 13q31.1 27 10 113.0 95.6
Under-expressed genes         
MAP3K10 5.4 2,352.3 0.002 19q13.2 36 19 47.4 135.1
DRD4 5.0 2,327.6 0.002 11p15.5 36 19 51.3 135.2
DLGAP3 4.8 2,297.9 0.002 1p35.3-p34.1 9 7 40.8 37.6
LBX1 2.7 1,358.5 0.002 10q24 36 19 46.4 152.6
TSPAN10* 7.9 4,674.7 0.002 17q25.3 9 8 55.0 46.0
c) Non-DS AMKL vs. MK        
Gene Value 'B' Value 'D' 'B'/'D' ratio Location Data points SD SD
'B' 'D' 'B' 'D'
Over-expressed genes        
TMEM241 2,754.1 17.6 156.443 18q11.2 14 8 89.9 115.8
CDYL2 1,613.5 13.1 122.994 16q23.2 7 8 128.9 69.8
MPV17L 1,857.8 24.4 76.280 16p13.11 7 8 119.5 65.0
ATP6V0D2 836.7 11.9 70.488 8q21.3a 21 10 169.4 82.9
CMBL 757.9 11.7 64.938 5p15.2 21 8 176.2 30.1
Under-expressed genes        
ILDR1 13.7 4,333.8 0.003 3q13.33 14 9 98.4 63.3
HIST3H3 3.9 1,313.0 0.003 1q42 40 19 78.0 137.9
TSPAN10* 12.1 4,674.7 0.003 17q25.3 7 8 88.1 46.0
MAP3K10 3.9 2,352.3 0.002 19q13.2 45 19 40.1 135.1
LBX1 2.0 1,358.5 0.001 10q24 45 19 85.7 152.6