Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

Pelleri, Maria Chiara; Piovesan, Allison; Caracausi, Maria; Berardi, Anna Concetta; Vitale, Lorenza; Strippoli, Pierluigi

doi:10.1186/s12920-014-0063-z

Table 3 List of the five most over- or under-expressed genes (all significantly, with q < 0.05)

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. non-DS AMKL
Gene	Value 'A'	Value 'B'	'A'/'B' ratio	Location	Data points		SD	SD
Gene	Value 'A'	Value 'B'	'A'/'B' ratio	Location	'A'	'B'	'A'	'B'
Over-expressed genes
SLITRK6	465.5	19.5	23.860	13q31.1	27	21	113.0	79.6
HDC	1,119.4	65.5	17.097	15q21-q22	36	45	98.8	249.4
ZNF587B	615.0	39.3	15.643	19q13.43^a	43	40	427.6	32.2
SOSTDC1	111.7	8.6	12.957	7p21.1	43	45	176.5	108.4
LOC100287628*	1,381.3	107.7	12.820	16p13.2	9	7	80.2	56.8
Under-expressed genes
Hs.587427*	19.8	407.8	0.049	7p15.2	18	14	28.9	353.3
SPINK2	13.1	285.1	0.046	4q12	36	45	81.8	115.0
Hs.602709*	15.8	370.2	0.043	11q13.2^a	9	7	33.1	256.9
RPS12	20.7	519.1	0.040	6q23.2	43	50	113.7	213.0
Hs.355689*	3.7	624.4	0.006	18q11.2^a	9	7	47.3	168.4
b) DS AMKL vs. MK
Gene	Value 'A'	Value 'D'	'A'/'D' ratio	Location	Data points		SD	SD
Gene	Value 'A'	Value 'D'	'A'/'D' ratio	Location	'A'	'D'	'A'	'D'
Over-expressed genes
TMEM241	1,036.6	17.6	58.885	18q11.2	18	8	57.7	115.8
CMBL	592.4	11.7	50.759	5p15.2	27	8	142.0	30.1
IFI27	467.8	11.6	40.474	14q32	36	82	90.0	27.6
CSRNP1	640.6	16.8	38.023	3p22	9	8	41.3	138.3
PTGS2	2,205.0	59.2	37.276	1q25.2 q25.3	63	20	156.4	131.6
APOC2* ^b	431.7	11.7	37.044	19q13.2	54	28	81.4	41.6
SLITRK6 ^b	465.5	13.3	35.057	13q31.1	27	10	113.0	95.6
Under-expressed genes
MAP3K10	5.4	2,352.3	0.002	19q13.2	36	19	47.4	135.1
DRD4	5.0	2,327.6	0.002	11p15.5	36	19	51.3	135.2
DLGAP3	4.8	2,297.9	0.002	1p35.3-p34.1	9	7	40.8	37.6
LBX1	2.7	1,358.5	0.002	10q24	36	19	46.4	152.6
TSPAN10*	7.9	4,674.7	0.002	17q25.3	9	8	55.0	46.0
c) Non-DS AMKL vs. MK
Gene	Value 'B'	Value 'D'	'B'/'D' ratio	Location	Data points		SD	SD
Gene	Value 'B'	Value 'D'	'B'/'D' ratio	Location	'B'	'D'	'B'	'D'
Over-expressed genes
TMEM241	2,754.1	17.6	156.443	18q11.2	14	8	89.9	115.8
CDYL2	1,613.5	13.1	122.994	16q23.2	7	8	128.9	69.8
MPV17L	1,857.8	24.4	76.280	16p13.11	7	8	119.5	65.0
ATP6V0D2	836.7	11.9	70.488	8q21.3^a	21	10	169.4	82.9
CMBL	757.9	11.7	64.938	5p15.2	21	8	176.2	30.1
Under-expressed genes
ILDR1	13.7	4,333.8	0.003	3q13.33	14	9	98.4	63.3
HIST3H3	3.9	1,313.0	0.003	1q42	40	19	78.0	137.9
TSPAN10*	12.1	4,674.7	0.003	17q25.3	7	8	88.1	46.0
MAP3K10	3.9	2,352.3	0.002	19q13.2	45	19	40.1	135.1
LBX1	2.0	1,358.5	0.001	10q24	45	19	85.7	152.6

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