Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

Table 4 Genomic segments significantly over- or under-expressed

a) DS AMKL vs. normal CB MK
Chr and location ^a	Segment start ^b	Segment end ^b	'A'/'E' ratio	q-value	Genes in the segment ^c
Over-expressed segments
chr3 3q22.1	130,000,001	130,500,000	80.36	0.00015	*COL6A5* + *COL6A6* + Hs.596709+ Hs.596805+ PIK3R4-
Under-expressed segments
chr7 7q11.23	77,000,001	77,500,000	0.48	0.00117	*GSAP* - *PTPN12* - LOC101059910- RSBN1L-AS1- RSBN1L- Hs.594486- Hs.720279- TMEM60- PHTF2-
chr4 4q12-q21	74,750,001	75,250,000	0.37	0.00119	*PF4* - *PPBP* - CXCL5- *CXCL3* - CXCL2- MTHFD2L- Hs.662627- EREG-
chr4 4q32.1	156,250,001	156,750,000	0.12	0.00000	*MAP9* - *GUCY1A3* - *Hs.612374* - *GUCY1B3* -
b) Non-DS AMKL vs. normal CB MK
Chr and location	Segment start	Segment end	'B'/'E' ratio	q-value	Genes in the segment
Over-expressed segments
chr3 3q22.1	130,000,001	130,500,000	116.13	0.00030	*COL6A5* + *COL6A6* + Hs.596709+ Hs.596805+ PIK3R4-
chr11 11p15	6,750,001	7,250,000	50.98	0.00117	OR6A2+ *OR10A5* + *OR10A4* + ZNF215- ZNF214- Hs.445849+ NLRP14+ RBMXL2- LOC100506238+
Under-expressed segments
chr4 4q12-q21	74,750,001	75,250,000	0.42	0.00003	*PF4* - *PPBP* - *CXCL5* - *CXCL3* - CXCL2- MTHFD2L- Hs.662627- EREG-

ISSN: 1755-8794