Skip to main content

Table 5 List of the five most over- or under-expressed genes (all significantly, with q <0.05)

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. normal CB MK

Gene

Value 'A'

Value 'E'

Ratio 'A'/'E'

Location

Data points

SD

SD

'A'

'E'

'A'

'E'

Over-expressed genes

        

PTPRO

679.7

15.1

45.063

12p13-p12

81

9

133.0

60.8

APOC2 a

431.7

9.9

43.477

19q13.2

54

10

81.4

43.4

IFI27

467.8

11.5

40.742

14q32

36

8

90.0

57.1

HDC

1,119.4

34.2

32.716

15q21-q22

36

8

98.8

168.1

VIPR2 ab

346.2

13.5

25.582

7q36.3

115

23

334.8

49.3

Under-expressed genes

        

CDKL1

4.6

174.3

0.027

14q21.3

45

9

65.3

99.0

ASAP2

19.1

734.1

0.026

2p24

36

8

95.4

67.3

GNG11

18.9

1,042.3

0.018

7q21

36

8

119.7

81.2

RPS12

20.7

1,157.2

0.018

6q23.2

43

15

113.7

112.4

OLFM4

8.9

499.3

0.018

13q14.3

36

7

83.9

121.5

b) Non-DS AMKL vs. normal CB MK

    

Gene

Value 'B'

Value 'E'

Ratio 'B'/'E'

Location

Data points

SD

SD

'B'

'E'

'B'

'E'

Over-expressed genes

        

PTPRO b

510.3

15.1

33.831

12p13-p12

97

9

137.8

60.8

CES3 b

287.4

12.2

23.511

16q22.1

47

9

335.8

73.8

SCD5 ab

544.7

27.2

19.992

4q21.22

61

18

290.3

73.9

TOP3B ab

150.2

7.5

19.922

22q11.22

60

14

431.8

19.7

MT1E ab

237.1

11.9

19.899

16q13

45

8

92.5

27.3

Under-expressed genes

        

Hs.23729a

2.3

85.1

0.027

1p13.2c

40

8

121.0

89.5

PDE6C

2.2

88.2

0.025

10q24

45

8

112.9

105.9

SPTLC3

4.8

203.7

0.023

20p12.1

47

9

86.5

110.7

SPATA1

7.0

356.2

0.020

1p22.3

40

7

127.4

77.9

OLFM4

9.7

499.3

0.020

13q14.3

45

7

105.1

121.5