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Table 5 List of the five most over- or under-expressed genes (all significantly, with q <0.05)

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. normal CB MK
Gene Value 'A' Value 'E' Ratio 'A'/'E' Location Data points SD SD
'A' 'E' 'A' 'E'
Over-expressed genes         
PTPRO 679.7 15.1 45.063 12p13-p12 81 9 133.0 60.8
APOC2 a 431.7 9.9 43.477 19q13.2 54 10 81.4 43.4
IFI27 467.8 11.5 40.742 14q32 36 8 90.0 57.1
HDC 1,119.4 34.2 32.716 15q21-q22 36 8 98.8 168.1
VIPR2 ab 346.2 13.5 25.582 7q36.3 115 23 334.8 49.3
Under-expressed genes         
CDKL1 4.6 174.3 0.027 14q21.3 45 9 65.3 99.0
ASAP2 19.1 734.1 0.026 2p24 36 8 95.4 67.3
GNG11 18.9 1,042.3 0.018 7q21 36 8 119.7 81.2
RPS12 20.7 1,157.2 0.018 6q23.2 43 15 113.7 112.4
OLFM4 8.9 499.3 0.018 13q14.3 36 7 83.9 121.5
b) Non-DS AMKL vs. normal CB MK     
Gene Value 'B' Value 'E' Ratio 'B'/'E' Location Data points SD SD
'B' 'E' 'B' 'E'
Over-expressed genes         
PTPRO b 510.3 15.1 33.831 12p13-p12 97 9 137.8 60.8
CES3 b 287.4 12.2 23.511 16q22.1 47 9 335.8 73.8
SCD5 ab 544.7 27.2 19.992 4q21.22 61 18 290.3 73.9
TOP3B ab 150.2 7.5 19.922 22q11.22 60 14 431.8 19.7
MT1E ab 237.1 11.9 19.899 16q13 45 8 92.5 27.3
Under-expressed genes         
Hs.23729a 2.3 85.1 0.027 1p13.2c 40 8 121.0 89.5
PDE6C 2.2 88.2 0.025 10q24 45 8 112.9 105.9
SPTLC3 4.8 203.7 0.023 20p12.1 47 9 86.5 110.7
SPATA1 7.0 356.2 0.020 1p22.3 40 7 127.4 77.9
OLFM4 9.7 499.3 0.020 13q14.3 45 7 105.1 121.5