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Table 7 List of the five genes most over- or under-expressed (all significantly, with q <0.05)

From: Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)

a) DS AMKL vs. TMD
Gene Value 'A' Value 'C' Ratio 'A'/'C' Location Data points SD SD
'A' 'C' 'A' 'C'
Over-expressed genes
ZNF587B 615.0 39.7 15.498 19q13.43c 43 20 427.6 20.9
IFI27 467.8 34.8 13.431 14q32 36 11 90.0 91.4
SLITRK6 465.5 38.7 12.036 13q31.1 27 9 113.0 84.5
BST2 a 117.6 14.8 7.967 19p13.1 36 11 260.0 98.8
ZNF521 143.0 19.6 7.309 18q11.2 18 6 113.5 58.6
Under-expressed genes     
ALS2CR12 4.2 15.8 0.268 2q33.1 18 6 80.3 103.2
GBP5 11.6 43.8 0.266 1p22.2 18 6 75.7 110.6
GHRH 14.7 67.1 0.219 20q11.2 43 20 97.7 257.0
SLFNL1 a 18.9 92.9 0.203 1p34.2 18 6 90.3 122.1
KIAA2022 24.3 297.9 0.081 Xq13.3 27 9 52.2 260.9
b) TMD vs. normal MK
Gene Value 'C' Value 'D' Ratio 'C'/'D' Location Data points SD SD
'C' 'D' 'C' 'D'
Over-expressed genes         
TMEM241 2,224.4 17.6 126.356 18q11.2 6 8 57.1 115.8
CMBL 1,063.5 11.7 91.126 5p15.2 9 8 168.8 30.1
PTGS2 2,256.4 59.2 38.145 1q25.2-q25.3 20 20 147.6 131.6
CGA 360.6 10.0 36.238 6q12-q21 14 19 159.7 27.3
TMEFF2 755.1 22.5 33.605 2q32.3 9 9 190.3 44.3
Under-expressed genes         
ILDR1 18.3 4,333.8 0.004 3q13.33 6 9 58.9 63.3
DRD4 9.3 2,327.6 0.004 11p15.5 11 19 52.3 135.2
HIST3H3 5.2 1,313.0 0.004 1q42 11 19 36.2 137.9
LBX1 4.3 1,358.5 0.003 10q24 11 19 26.6 152.6
MAP3K10 7.4 2,352.3 0.003 19q13.2 11 19 28.8 135.1
c) TMD vs. normal CB MK
Gene Value 'C' Value 'E' Ratio 'C'/'E' Location Data points SD SD
'C' 'E' 'C' 'E'
Over-expressed genes
CGA 360.6 8.0 44.869 6q12-q21 14 8 159.7 39.9
PTPRO b 523.1 15.1 34.680 12p13-p12 25 9 116.8 60.8
CLCA1 b 319.2 9.9 32.380 1p22.3 20 8 116.7 17.5
APOC2 ab 301.6 9.9 30.372 19q13.2 17 10 66.6 43.4
HDC ab 918.0 34.2 26.830 15q21-q22 11 8 59.9 168.1
Under-expressed genes
CDKL1 5.9 174.3 0.034 14q21.3 14 9 82.0 99.0
GNG11 34.3 1,042.3 0.033 7q21 11 8 80.1 81.2
RHOBTB1 7.7 241.3 0.032 10q21.2 20 8 49.7 97.4
RPS12 34.6 1,157.2 0.030 6q23.2 20 15 77.4 112.4
OLFM4 10.0 499.3 0.020 13q14.3 11 7 56.0 121.5