Figure 3

FLAGS genes are affected by rare variants predicted to be less deleterious than the variants affecting known disease-genes. (a) A boxplot distribution of proportion of variants with CADD score <10. The Y-axis plots the proportion of variants within each gene set having a Phred-scaled CADD score of <10. The proportion was calculated per individual gene. (b) A boxplot distribution of proportion of variants with CADD score >20. The Y-axis plots the proportion of variants within each gene set having a Phred-scaled CADD score of >20. The proportion was calculated per individual gene.