Enriched synaptic long-term potentiation canonical pathway , identified by ingenuity pathway analysis based on differentially expressed genes ( P value < 0.05 ) with the ordinary student’s t -test. The pathway was also detected by onto-tools pathway-express. (A) Week 8 TPM group (29 genes: ATF2, CAMK2D, CAMK2G, CREB1, EP300, GNAQ, GRINA, MAP2K1, MAPK1, MAPK3, PLCB2, PPP1CA, PPP1CB, PPP1CC, PPP1R10, PPP1R12A, PPP1R14B, PPP1R7, PPP3CB, PPP3CC, PRKACA, PRKACB, PRKAR1A, PRKCD, PRKCH, PRKCI, PRKCQ, PRKCZ, and RRAS); and (B) Week 12 TPM group (10 genes; ATF4, CREB5, EP300, GNAQ, KRAS, PPP1R10, PRKACB, PRKAR2A, PRKCB, and PRKCQ). Symbols with a single border represent single genes; those with a double border represent complexes of genes or the possibility that alternative genes might act in the pathway. Red symbols represent up-regulated gene clusters and green symbols represent down-regulated clusters.