Table 1 A list of 48 representative genes significantly up-regulated in week 8 topiramate group a
Gene symbol | Gene name | Week 8 TPM | ||
|---|---|---|---|---|
|  |  | FC ± SD b | P Value c | FDR d |
Cell adhesion / Motion | ||||
CD164 | CD164 molecule, sialomucin | 2.67 ± 0.38 | 1.00 × 10−6 | 5.07 × 10−5 |
ITGA4 | Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 2.24 ± 0.27 | 4.00 × 10−6 | 1.31 × 10−4 |
ITGB1 | Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 2.20 ± 0.25 | 1.10 × 10−5 | 2.64 × 10−4 |
SCYL2 | SCY1-like 2 (S. cerevisiae) | 2.45 ± 0.30 | 4.00 × 10−6 | 1.31 × 10−4 |
Synaptic plasticity and nervous system development / function | ||||
DLG1 | Discs, large homolog 1 (Drosophila) | 1.66 ± 0.12 | 2.00 × 10−6 | 8.22 × 10−5 |
GDI2 | GDP dissociation inhibitor 2 | 1.63 ± 0.09 | <1.00 × 10−6 | <1.00 × 10−5 |
HIF1A | Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 2.22 ± 0.26 | 4.00 × 10−6 | 1.31 × 10−4 |
SCFD1 | Sec1 family domain containing 1 | 1.63 ± 0.12 | 3.00 × 10−6 | 1.09 × 10−4 |
SNAP23 | Synaptosomal-associated protein, 23kDa | 1.95 ± 0.19 | 2.00 × 10−6 | 8.22 × 10−5 |
TRAK2 | Trafficking protein, kinesin binding 2 | 1.44 ± 0.07 | <1.00 × 10−6 | <1.00 × 10−5 |
ZFR | Zinc finger RNA binding protein | 2.14 ± 0.22 | 1.00 × 10−6 | 5.07 × 10−5 |
Signal transduction | ||||
AKAP11 | A kinase (PRKA) anchor protein 11 | 2.23 ± 0.29 | 1.10 × 10−5 | 2.60 × 10−4 |
CCNYL1 | Cyclin Y-like 1 | 1.62 ± 0.10 | 3.00 × 10−6 | 1.09 × 10−4 |
ERBB2IP | Erbb2 interacting protein | 2.28 ± 0.23 | <1.00 × 10−6 | <1.00 × 10−5 |
FGFR1OP2 | FGFR1 oncogene partner 2 | 1.57 ± 0.11 | 4.00 × 10−6 | 1.31 × 10−4 |
MAPK1IP1L | Mitogen-activated protein kinase 1 interacting protein 1-like | 1.39 ± 0.06 | <1.00 × 10−6 | <1.00 × 10−5 |
PIK3AP1 | Phosphoinositide-3-kinase adaptor protein 1 | 1.70 ± 0.14 | 5.00 × 10−6 | 1.54 × 10−4 |
PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 2.04 ± 0.23 | 7.00 × 10−6 | 1.92 × 10−4 |
PIP5K3 | Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III | 1.95 ± 0.20 | 1.00 × 10−5 | 2.53 × 10−4 |
PTEN | Phosphatase and tensin homolog | 2.01 ± 0.10 | <1.00 × 10−6 | <1.00 × 10−5 |
RABEP1 | Rabaptin, RAB GTPase binding effector protein 1 | 1.42 ± 0.08 | 5.00 × 10−6 | 1.54 × 10−4 |
RAP2A | RAP2A, member of RAS oncogene family | 1.75 ± 0.15 | 8.00 × 10−6 | 2.13 × 10−4 |
RAP2C | RAP2C, member of RAS oncogene family | 1.84 ± 0.16 | 3.00 × 10−6 | 1.09 × 10−4 |
SKAP2 | Src kinase associated phosphoprotein 2 | 1.76 ± 0.15 | 5.00 × 10−6 | 1.54 × 10−4 |
SOS2 | Son of sevenless homolog 2 (Drosophila) | 2.51 ± 0.25 | <1.00 × 10−6 | <1.00 × 10−5 |
TGFBR2 | Transforming growth factor, beta receptor II (70/80kDa) | 1.49 ± 0.09 | 8.00 × 10−6 | 2.13 × 10−4 |
TOB1 | Transducer of ERBB2, 1 | 2.28 ± 0.27 | 1.00 × 10−6 | 5.07 × 10−5 |
ZFAND6 | Zinc finger, AN1-type domain 6 | 2.25 ± 0.20 | <1.00 × 10−6 | <1.00 × 10−5 |
Ubiquitination/Intracellular protein transport | ||||
CUL5 | Cullin 5 | 2.25 ± 0.29 | 6.00 × 10−6 | 1.72 × 10−4 |
FBXL5 | F-box and leucine-rich repeat protein 5 | 1.69 ± 0.09 | <1.00 × 10−6 | <1.00 × 10−5 |
FBXO28 | F-box protein 28 | 1.45 ± 0.08 | 5.00 × 10−6 | 1.54 × 10−4 |
PCNP | PEST proteolytic signal containing nuclear protein | 2.54 ± 0.35 | 3.00 × 10−6 | 1.09 × 10−4 |
PSMD12 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 1.77 ± 0.12 | <1.00 × 10−6 | <1.00 × 10−5 |
RNF11 | Ring finger protein 11 | 3.29 ± 0.39 | <1.00 × 10−6 | <1.00 × 10−5 |
RNF149 | Ring finger protein 149 | 1.51 ± 0.10 | 8.00 × 10−6 | 2.13 × 10−4 |
SEC62 | SEC62 homolog (S. cerevisiae) | 1.69 ± 0.12 | <1.00 × 10−6 | <1.00 × 10−5 |
SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 1.64 ± 0.10 | <1.00 × 10−6 | <1.00 × 10−5 |
SRP54 | Signal recognition particle 54kDa | 1.56 ± 0.10 | 3.00 × 10−6 | 1.09 × 10−4 |
UBE2D1 | Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 2.41 ± 0.30 | 2.00 × 10−6 | 8.22 × 10−5 |
XPO1 | Exportin 1 (CRM1 homolog, yeast) | 1.98 ± 0.18 | <1.00 × 10−6 | <1.00 × 10−5 |
YME1L1 | YME1-like 1 (S. cerevisiae) | 1.69 ± 0.11 | <1.00 × 10−6 | <1.00 × 10−5 |
Mitochondrial function / Metabolism and energy pathways | ||||
ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 2.11 ± 0.24 | 9.00 × 10−6 | 2.38 × 10−4 |
GALNT7 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) | 1.87 ± 0.17 | 3.00 × 10−6 | 1.09 × 10−4 |
MAN1A1 | Mannosidase, alpha, class 1A, member 1 | 2.26 ± 0.28 | 6.00 × 10−6 | 1.72 × 10−4 |
NUDT5 | Nudix (nucleoside diphosphate linked moiety X)-type motif 5 | 1.34 ± 0.04 | <1.00 × 10−6 | <1.00 × 10−5 |
PGK1 | Phosphoglycerate kinase 1 | 1.35 ± 0.06 | 6.00 × 10−6 | 1.72 × 10−4 |
SLC25A46 | Solute carrier family 25, member 46 | 2.20 ± 0.25 | 3.00 × 10−6 | 1.09 × 10−4 |
TXNL1 | Thioredoxin-like 1 | 1.49 ± 0.08 | 1.00 × 10−6 | 5.07 × 10−5 |