Table 2 A List of 45 representative genes significantly down-regulated in week 8 topiramate group a
Gene symbol | Gene name | Week 8 TPM | ||
|---|---|---|---|---|
|  |  | FC ± SD b | P Value c | FDR d |
Cell adhesion / Motion | ||||
CDC2L2 | Cell division cycle 2-like 2 | −1.39 ± 0.07 | 1.10 × 10−5 | 2.64 × 10−4 |
CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | −2.01 ± 0.19 | 1.00 × 10−6 | 5.07 × 10−5 |
EMILIN2 | Elastin microfibril interfacer 2 | −1.41 ± 0.05 | <1.00 × 10−6 | <1.00 × 10−5 |
JAK3 | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | −1.68 ± 0.11 | 1.00 × 10−6 | 5.07 × 10−5 |
TUBB2C | Tubulin, beta 2C | −1.39 ± 0.06 | 2.00 × 10−6 | 8.22 × 10−5 |
Nervous system development and function / synaptic plasticity | ||||
ADAT1 | Adenosine deaminase, tRNA-specific 1 | −1.61 ± 0.08 | <1.00 × 10−6 | <1.00 × 10−5 |
CIRBP | Cold inducible RNA binding protein | −1.74 ± 0.13 | 1.00 × 10−6 | 5.07 × 10−5 |
DGCR14 | 3-phosphoinositide dependent protein kinase-1 | −1.45 ± 0.04 | <1.00 × 10−6 | <1.00 × 10−5 |
FKBP4 | FK506 binding protein 4, 59 kDa | −1.49 ± 0.10 | 6.00 × 10−6 | 1.72 × 10−4 |
NAPA | N-ethylmaleimide-sensitive factor attachment protein, alpha | −2.04 ± 0.21 | 1.00 × 10−6 | 5.07 × 10−5 |
P2RX1 | Purinergic receptor P2X, ligand-gated ion channel, 1 | −1.72 ± 0.13 | 2.00 × 10−6 | 8.22 × 10−5 |
PRKACA | Solute carrier family 1 (glial high affinity glutamate transporter), member 3 | −1.69 ± 0.15 | 1.10 × 10−5 | 2.64 × 10−4 |
SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | −1.23 ± 0.04 | 3.00 × 10−6 | 1.09 × 10−4 |
TRIM8 | Tripartite motif-containing 8 | −1.45 ± 0.06 | 4.00 × 10−6 | 1.31 × 10−4 |
Signaling transduction | ||||
ARHGEF2 | Rho/rac guanine nucleotide exchange factor (GEF) 2 | −1.62 ± 0.11 | 2.00 × 10−6 | 8.22 × 10−5 |
BCR | Breakpoint cluster region | −1.43 ± 0.06 | <1.00 × 10−6 | <1.00 × 10−5 |
GRINA | Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 | −2.49 ± 0.28 | <1.00 × 10−6 | <1.00 × 10−5 |
LIMK2 | LIM domain kinase 2 | −3.05 ± 0.44 | 4.00 × 10−6 | 1.31 × 10−4 |
PHPT1 | Phosphohistidine phosphatase 1 | −1.33 ± 0.06 | 7.00 × 10−6 | 1.92 × 10−4 |
PLCB2 | Phospholipase C, beta 2 | −1.93 ± 0.13 | <1.00 × 10−6 | <1.00 × 10−5 |
RHOT2 | Ras homolog gene family, member T2 | −1.46 ± 0.05 | <1.00 × 10−6 | <1.00 × 10−5 |
Ubiquitination / Intracellular protein transport | ||||
AP2A1 | Adaptor-related protein complex 2, alpha 1 subunit | −2.04 ± 0.20 | 1.10 × 10−5 | 2.64 × 10−4 |
NPEPL1 | Aminopeptidase-like 1 | −1.26 ± 0.03 | <1.00 × 10−6 | <1.00 × 10−5 |
SHARPIN | SHANK-associated RH domain interactor | −2.13 ± 0.26 | 1.00 × 10−5 | 2.53 × 10−4 |
TRAPPC5 | Trafficking protein particle complex 5 | −1.58 ± 0.11 | 6.00 × 10−6 | 1.72 × 10−4 |
UBE2M | Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) | −1.70 ± 0.12 | 1.00 × 10−6 | 5.07 × 10−5 |
UBXN6 | UBX domain protein 6 | −2.40 ± 0.29 | 2.00 × 10−6 | 8.22 × 10−5 |
USP4 | Ubiquitin specific peptidase 4 (proto-oncogene) | −1.46 ± 0.06 | 2.00 × 10−6 | 8.22 × 10−5 |
WBP2 | WW domain binding protein 2 | −1.85 ± 0.18 | 4.00 × 10−6 | 1.31 × 10−4 |
Mitochondrial function / metabolism and energy pathways | ||||
ATAD3B | ATPase family, AAA domain containing 3B | −1.47 ± 0.07 | <1.00 × 10−6 | <1.00 × 10−5 |
B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | −1.26 ± 0.04 | 1.00 × 10−6 | 5.07 × 10−5 |
COASY | Coenzyme A synthase | −1.29 ± 0.06 | 1.20 × 10−5 | 2.79 × 10−4 |
COX5B | Cytochrome c oxidase subunit Vb | −1.44 ± 0.09 | 1.20 × 10−5 | 2.79 × 10−4 |
GANAB | Glucosidase, alpha; neutral AB | −1.63 ± 0.08 | <1.00 × 10−6 | <1.00 × 10−5 |
MRPL37 | Mitochondrial ribosomal protein L37 | −1.30 ± 0.04 | <1.00 × 10−6 | <1.00 × 10−5 |
NAGK | N-acetylglucosamine kinase | −1.30 ± 0.05 | 4.00 × 10−6 | 1.31 × 10−4 |
NDUFV3 | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10 kDa | −1.63 ± 0.08 | <1.00 × 10−6 | <1.00 × 10−5 |
PFKL | Phosphofructokinase, liver | −1.53 ± 0.10 | 3.00 × 10−6 | 1.09 × 10−4 |
UROD | Uroporphyrinogen decarboxylase | −1.35 ± 0.06 | 5.00 × 10−6 | 1.54 × 10−4 |
Immune system function | ||||
CISH | Cytokine inducible SH2-containing protein | −1.34 ± 0.05 | 1.00 × 10−6 | 5.07 × 10−5 |
HLA-E | Major histocompatibility complex, class I, E | −1.25 ± 0.04 | <1.00 × 10−6 | <1.00 × 10−5 |
JMJD3 | Jumonji domain containing 3, histone lysine demethylase | −2.03 ± 0.16 | <1.00 × 10−6 | <1.00 × 10−5 |
MSRB2 | Methionine sulfoxide reductase B2 | −1.68 ± 0.13 | 2.00 × 10−6 | 8.22 × 10−5 |
OAS1 | 2′,5′-oligoadenylate synthetase 1, 40/46 kDa | −1.84 ± 0.15 | 1.00 × 10−6 | 5.07 × 10−5 |
TAPBP | TAP binding protein (tapasin) | −1.60 ± 0.06 | <1.00 × 10−6 | <1.00 × 10−5 |