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Table 1 Differentially expressed proteins in different subtypes of clinically nonfunctional pituitary adenomas versus controls

From: Heterogeneity analysis of the proteomes in clinically nonfunctional pituitary adenomas

SSP no. Protein name Swiss-Prot no. NF-NFPA LH-NFPA FSH-NFPA LH/FSH-NFPA
1011 Chain 1: somatotropin P01241 180.6(−) 44.1(−) 82.6(−) 90.5(−)
1017 Chain 1: somatotropin P01241   13.3(−)   
1017 Splice isoform 2 of somatotropin precursor P01241 isoform   13.3(−)   
1102 Chain 1: somatotropin P01241 20.2(−) 6.5(−) 9.1(−) 9.3(−)
1103 Somatotropin precursor P01241 14.1(−) 2.9(−) 3.3(−) 5.8(−)
1103 Growth hormone variant precursor P01242 14.1(−) 2.9(−) 3.3(−) 5.8(−)
1109 Chain 1: somatotropin P01241 isoform (−−) 128.3(−) 69.4(−) (−−)
1121 Chain 1: somatotropin P01241 6.2(−) 2.8(−) 2.7(−) 3.3(−)
1122 Chain 1: somatotropin P01241 48.1(−) (−−) 7.5(−) 8.1(−)
1123 Chain 1: somatotropin P01241 17.3(−) 4.4(−) 6.4(−) (−−)
2002 Splice isoform 2 of somatotropin precursor P01241 isoform 9.7(−) 3.9(−) 3.2(−) 5.4(−)
2003 Chain 1: somatotropin P01241 (−−) 88.8(−) 25.0(−) (−−)
2101 Chain 1: somatotropin P01241 27.8(−) (−−)   17.4(−)
2106 Chain 1: somatotropin P01241 (−−) 9.4(−) 2.2(−) 51.2(−)
2115 Chain 1: somatotropin P01241 (−−) 32.1(−) (−−) (−−)
2128 Chain 1: somatotropin P01241 (−−) 82.1(−) 67.4(−) 478.6(−)
2129 Chain 1: somatotropin P01241 13.4(−) 6.7(−) 4.3(−) 5.5(−)
3004 Chain 1: somatotropin P01241 42.0(−) 37.0(−) 21.2(−) 13.6(−)
3107 Chain 1: somatotropin P01241 30.5(−) (−−) 19.1(−) 34.9(−)
4106 Chain 1: prolactin P01236 8.3(−) 12.6(−) 46.2(−) 99.9(−)
4215 Prolactin precursor P01236 4.9(−) 4.1(−)   3.8(−)
4216 Chain 1: prolactin P01236   26.2(−) 14.6(−) 12.3(−)
5114 Chain 1: prolactin P01236 (−−) 20.1(−) 17.6(−) 19.0(−)
6109 Chain 1: prolactin P01236 (−−) 36.7(−) (−−) 19.7(−)
6119 Chain 1: prolactin P01236 (−−) 33.6(−) 11.3(−) 32.6(−)
0020 Splice isoform IL15-S21AA of interleukin-15 precursor P40933-2 isoform (−−) (−−) 1.6(−) 2.7(−)
0029 Chain 1: Factor X light chain P00742 (−−) (−−) 29.3(−) 38.9(−)
0511 Cytokeratin 16 P08779 28.8(−) 2.1(−) 15.7(−) 18.5(−)
0112 Alpha crystallin C chain Q9UJY1 (−−) 2.3(−) (−−) (−−)
0812 Chain 1: Endoplasmin (Tumor rejection antigen 1) P14625 11.0(−) 4.4(−)   
1010 14-3-3 protein tau P27348 (−−) (−−) 6.4(−) 15.5(−)
1012 Splice isoform 3 of alpha-s1 casein precursor P47710-3 isoform 17.8(−)    
1117 Chain 1: apolipoprotein A-I P02647 2.1(−)    
1311 Secretagogin O76038 6.6(−) 2.1(−) 2.3(−) 3.4(−)
1402 Mu-crystallin homolog Q14894 16.3(−) 4.6(−) 2.4(−) 4.6(−)
1404 Chain 1: MIMECAN P20774 38.0(−) 6.1(−) 9.1(−) 16.2(−)
1806 Tissue transglutaminase P21980 (−−) 17.1(−) (−−) (−−)
2001 CD59 glycoprotein P13987 9.5(−)   2.4(−) 4.1(−)
2303 Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform Q00007 8.2(−)   2.6(−)  
2311 L-Myc-1 protooncogene protein P12524    7.4(−)  
2624 Chain 1: dipeptidyl-peptidase II Q9UHL4 9.3(−) 2.5(−)   5.3(−)
3210 Heat shock protein 27 P04792 2.4(−)   4.9(−)  
4001 ATP binding protein associated with cell differentiation O14530 11.4(−) 2.3(−) 2.7(−) 4.4(−)
4921 Chain 1: collagen alpha 2 (VI) chain P12110   5.3(−) 14.7(−)  
5003 Hemoglobin beta-2 chain P18988 3.1(−) 2.1(−)   
6103 N6-adenosine-methyltransferase 70 kDa subunit Q86U44 6.2(−) 6.5(−) (−−) 8.3(−)
7004 Hemoglobin beta unit variant gi1066765 (−−) 176.7(−) (−−) (−−)
7014 Hemoglobin beta-2 chain P18988 (−−) 29.4(−) 28.9(−) 99.4(−)
7016 Hemoglobin alpha-2 chain P01968    20.2(−) 13.3(−)
8101 Chain 1: insulin-like growth factor binding P24592 (−−) 2.9(−) 20.9(−) 5.0(−)
8102 Chain 1: phospholipid hydroperoxide glutathione peroxidase P36969   3.9(−) 2.1(−) 14.4(−)
8208 Ig kappa chain V-III region SIE P01620   4.1(−) 32.5(−)  
0118 Lactoylglutathione lyase Q04760   9.1(+) 10.2(+)  
1105 Lactoylglutathione lyase Q04760   6.6(+) 8.3(+) 5.1(+)
1107 NADH-ubiquinone oxidoreductase 23 kDa O00217   4.9(+) 5.2(+)  
1608 ATP synthase beta chain, mitochondrial precursor P06576 5.0(+) 3.1(+)   2.8(+)
1610 Vimentin P08670 5.5(+) 2.6(+)   
1705 Rab GDP dissociation inhibitor alpha P31150 9.4(+) 5.8(+)   
2008 Enhancer of rudimentary homolog Q14259   5.0(+) 3.7(+)  
2310 F-actin capping protein beta subunit P47756 2.7(+) 2.2(+) 6.5(+) 3.0(+)
2310 Splice isoform 2 of F-actin capping protein beta subunit P47756-2 isoform 2.7(+) 2.2(+) 6.5(+) 3.0(+)
2416 Zinc finger protein 266 Q14584 3.4(+) 2.4(+) 7.3(+) 2.8(+)
2419 Guanine nucleoide-binding protein G(O), alpha subunit 1 P09471 7.3(+) 2.1(+) 9.1(+) 9.5(+)
2419 Guanine nucleotide-binding protein G(O), alpha subunit 2 P29777 7.3(+) 2.1(+) 9.1(+) 9.5(+)
3013 Acyl-CoA-binding protein P07108   2.7(+) 4.3(+)  
3222 Chain 1: Endoplasmic reticulum protein ERP29 P30040    4.1(+)  
4012 Cytochrome c oxidase polypeptide VIb P14854   4.4(+) 8.7(+)  
4313 Aldose reductase P15121 5.7(+) 9.6(+) 14.6(+) 8.1(+)
4616 Tryptophan 5-hydroxylase (Neuronal tryptophan hydroxylase) Q8IWU9 10.6(+) 2.1(+) 7.8(+) 8.3(+)
5207 Glutathione S-transferase Mu-2 P28161 2.5(+) 2.8(+) 4.2(+) 2.9(+)
5617 Proto-oncogene tyrosine-protein kinase FYN P06241 2.8(+)   3.9(+)  
6115 Neuronal protein NP25 Q9UI15   4.9(+) 4.6(+)  
6508 Isocitrate dehydrogenase [NADP] cytoplasmic O75874 6.1(+) 6.7(+) 8.7(+) 4.4(+)
7503 Peroxisomal acyl-coenzyme A thioester hydrolase 2a P49753 2.8(+) 2.0(+) 2.2(+) 2.5(+)
7519 Chain 1: matrix metalloproteinase-19 Q99542     3.1(+)
7106 40 kDa peptidyl-prolyl cis-trans isomerase Q08752 4.3(+)   5.0(+) 5.1(+)
  1. LH-NFPA = NFPA that expressed leuteinizing hormone, or lutropin; FSH-NFPA = NFPA that expressed follicle-stimulating hormone, or follitropin; LH/FSH-NFPA = NFPA that expressed both follicle-stimulating hormone and leuteinizing hormone; NF-NFPA = NFPA that had negative immunohistochemical stains for ACTH, FSH, GH, LH, prolactin, and TSH. Each adenoma was graded blindly by a neuropathologist from 0–4 for intensity of staining for each peptide hormone. (−) = decreased relative to controls; (−−) = lost relative to controls; (+) = increased relative to controls; (+/−) = no change relative to controls.