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Table 4 GSEA results for modules associated with exacerbations phenotypes (gene sets with FDR q-value < 0.25 are shown and viral response gene sets are in bold)

From: Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods

Module name Gene set description ID Set overlap P-value FDR q-value
White (negative)* NAIVE_BCELL_VS_MONOCYTE_UP GSE22886 15 0.084 0.207
CD4_TCELL_VS_BCELL_DN GSE10325 18 0.122 0.230
BCELL_VS_MONOCYTE_DAY7_FLU_VACCINE_P GSE29618 17 0.185 0.216
Royalblue (positive)* NAIVE_VS_PD1LOW_CD8_TCELL_DN GSE26495 28 0.004 0.048
HEALTHY_VS_RSV_INF_INFANT_PBMC_UP GSE34205 15 0.016 0.062
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN   18 0.055 0.151
Lightgreen (negative)* BCELL_VS_MDC_DAY7_FLU_VACCINE_UP GSE29618 17 0.006 0.095
CD4_TCELL_VS_BCELL_DN GSE10325 19 0.012 0.05
BCELL_VS_MDC_UP GSE29618 15 0.012 0.043
LUPUS_CD4_TCELL_VS_LUPUS_BCELL_DN GSE10325 20 0.01 0.046
DODD_NASOPHARYNGEAL_CARCINOMA_UP   15 0.023 0.068
BCELL_VS_MONOCYTE_DAY7_FLU_VACCINE_UP GSE29618 21 0.025 0.064
BCELL_VS_MYELOID_UP GSE10325 15 0.045 0.064
NAIVE_BCELL_VS_MONOCYTE_UP GSE22886 17 0.06 0.078
BCELL_VS_MONOCYTE_UP GSE29618 23 0.075 0.121
CAGGTG_V$E12_Q6   16 0.116 0.149
MEMORY_CD4_TCELL_VS_BCELL_DN GSE3982 17 0.137 0.14
Darkturquoise (positive)* NAIVE_VS_PD1LOW_CD8_TCELL_DN GSE26495 26 0.057 0.090
NAIVE_VS_PD1HIGH_CD8_TCELL_DN GSE26495 19 0.158 0.166
Darkgrey (positive)* CTRL_VS_NEWCASTLE_VIRUS_DC_8H_DN GSE18791 30 0.000 0.012
BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE   18 0.003 0.038
UNSTIM_VS_4H_LPS_DC_TRANSLATED_RNA_DN GSE14000 23 0.002 0.030
MOSERLE_IFNA_RESPONSE   17 0.011 0.104
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP   20 0.016 0.094
UNSTIM_VS_NEWCATSLE_VIRUS_DC_18H_DN GSE18791 19 0.013 0.093
UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN GSE18791 31 0.031 0.105
CTRL_VS_NEWCASTLE_VIRUS_DC_10H_DN GSE18791 21 0.013 0.095
CTRL_VS_NEWCASTLE_VIRUS_DC_12H_DN GSE18791 19 0.026 0.134
UNSTIM_VS_4H_LPS_DC_DN GSE14000 24 0.031 0.141
UNSTIM_VS_NEWCATSLE_VIRUS_DC_10H_DN GSE18791 26 0.034 0.161
CTRL_VS_NEWCASTLE_VIRUS_DC_4H_DN GSE18791 22 0.052 0.166
CTRL_VS_NEWCASTLE_VIRUS_DC_6H_DN GSE18791 27 0.054 0.170
BCELL_VS_LUPUS_BCELL_DN GSE10325 17 0.094 0.250
HECKER_IFNB1_TARGETS   21 0.102 0.246
  1. *Positive or negative correlation between module and phenotype.