Table 3 KEGG pathway enrichment analysis for the genes comprising signature 3 (101.6.3)

KEGG_PATHWAY

hsa04110:Cell cycle

36

0.47

9.03E-20

E2F1, E2F2, E2F3, TTK, CHEK1, PTTG1, CCNE2, CCNE1, CDKN2A, MCM7, CDKN2C, CDKN2D, ORC6L, TFDP2, BUB1, CCNA2, STAG1, CDC7, CDC6, RBL1, SKP2, ESPL1, CDC20, MCM2, CDC25C, MCM4, CDC25A, CDC25B, CDKN1C, CCNB1, CCNB2, MAD2L1, PLK1, GSK3B, BUB1B, MAD2L2

225

125

5085

6.51

1.29E-17

1.29E-17

1.07E-16

KEGG_PATHWAY

hsa03030:DNA replication

12

0.16

2.15E-07

RFC5, PRIM1, MCM7, RFC4, POLE2, LIG1, POLA1, POLA2, MCM2, RNASEH2A, MCM4, FEN1

225

36

5085

7.53

3.08E-05

1.54E-05

2.55E-04

KEGG_PATHWAY

hsa04114:Oocyte meiosis

18

0.23

4.82E-06

SGOL1, AURKA, CDC20, ESPL1, PTTG1, CDC25C, CCNE2, CCNB1, CCNE1, CCNB2, MAD2L1, ADCY9, CALML3, PLK1, BUB1, FBXO5, CAMK2B, MAD2L2

225

110

5085

3.7

6.89E-04

2.30E-04

0.01

KEGG_PATHWAY

hsa04914:Progesterone-mediated oocyte maturation

14

0.18

8.26E-05

HSP90AA1, CDC25C, CDC25A, CDC25B, CCNB1, CCNB2, MAD2L1, KRAS, ADCY9, PLK1, BUB1, MAD2L2, PIK3R3, CCNA2

225

86

5085

3.68

0.01

0

0.1

KEGG_PATHWAY

hsa04115:p53 signaling pathway

10

0.13

0

CCNE2, CCNB1, CCNE1, CDKN2A, CCNB2, RRM2, TSC2, CHEK1, PMAIP1, GTSE1

225

68

5085

3.32

0.32

0.07

3.16

KEGG_PATHWAY

hsa05222:Small cell lung cancer

11

0.14

0

E2F1, CCNE2, E2F2, CCNE1, CKS1B, E2F3, PTK2, SKP2, PIAS2, PIK3R3, ITGA2B

225

84

5085

2.96

0.4

0.08

4.12

KEGG_PATHWAY

hsa04360:Axon guidance

14

0.18

0

PLXNA1, EFNB3, PLXNA2, DPYSL5, EPHB1, PTK2, KRAS, UNC5B, PAK2, UNC5A, FYN, GSK3B, SRGAP1, SRGAP2

225

129

5085

2.45

0.45

0.08

4.83

KEGG_PATHWAY

hsa00240:Pyrimidine metabolism

11

0.14

0.01

PRIM1, TYMS, POLR3K, POLE2, RRM2, RRM1, DCK, POLA1, POLA2, NME7, TK1

225

95

5085

2.62

0.71

0.14

9.63

KEGG_PATHWAY

hsa05219:Bladder cancer

7

0.09

0.01

E2F1, RPS6KA5, E2F2, E2F3, CDKN2A, KRAS, PGF

225

42

5085

3.77

0.74

0.14

10.67

KEGG_PATHWAY

hsa05215:Prostate cancer

10

0.13

0.02

E2F1, CCNE2, E2F2, CCNE1, E2F3, HSP90AA1, KRAS, GSK3B, PIK3R3, CTNNB1

225

89

5085

2.54

0.9

0.2

17.14

KEGG_PATHWAY

hsa00230:Purine metabolism

14

0.18

0.02

POLR3K, POLA1, DCK, POLA2, HPRT1, GMPS, NME7, GART, PRIM1, ADCY9, POLE2, RRM2, PKLR, RRM1

225

153

5085

2.07

0.91

0.2

18.08

KEGG_PATHWAY

hsa03410:Base excision repair

6

0.08

0.02

POLE2, UNG, LIG1, MBD4, NTHL1, FEN1

225

35

5085

3.87

0.92

0.19

18.86

KEGG_PATHWAY

hsa05214:Glioma

8

0.1

0.02

E2F1, E2F2, E2F3, CDKN2A, KRAS, CALML3, CAMK2B, PIK3R3

225

63

5085

2.87

0.94

0.2

21.16

KEGG_PATHWAY

hsa05200:Pathways in cancer

23

0.3

0.03

E2F1, E2F2, FZD8, CKS1B, MSH6, E2F3, HSP90AA1, PGF, FGF9, SKP2, BIRC5, FZD2, CTNNB1, CTNNA2, CCNE2, CCNE1, PTK2, CDKN2A, KRAS, GSK3B, PIAS2, PIK3R3, ITGA2B

225

328

5085

1.58

0.99

0.27

30.48

KEGG_PATHWAY

hsa00670:One carbon pool by folate

4

0.05

0.03

TYMS, MTHFD2, SHMT2, GART

225

16

5085

5.65

0.99

0.26

31.03

KEGG_PATHWAY

hsa04916:Melanogenesis

9

0.12

0.07

FZD8, KRAS, ADCY9, CALML3, GSK3B, GNAS, CAMK2B, FZD2, CTNNB1

225

99

5085

2.05

1

0.47

57.19

KEGG_PATHWAY

hsa05210:Colorectal cancer

8

0.1

0.08

FZD8, MSH6, KRAS, GSK3B, BIRC5, FZD2, PIK3R3, CTNNB1

225

84

5085

2.15

1

0.48

60.57

KEGG_PATHWAY

hsa03430:Mismatch repair

4

0.05

0.08

RFC5, MSH6, RFC4, LIG1

225

23

5085

3.93

1

0.48

61.82

KEGG_PATHWAY

hsa05223:Non-small cell lung cancer

6

0.08

0.09

E2F1, E2F2, E2F3, CDKN2A, KRAS, PIK3R3

225

54

5085

2.51

1

0.5

66.23

KEGG_PATHWAY

hsa05218:Melanoma

7

0.09

0.09

E2F1, E2F2, E2F3, CDKN2A, KRAS, FGF9, PIK3R3

225

71

5085

2.23

1

0.5

67.79

KEGG_PATHWAY

hsa05212:Pancreatic cancer

7

0.09

0.1

E2F1, E2F2, E2F3, CDKN2A, KRAS, PGF, PIK3R3

225

72

5085

2.2

1

0.5

69.77