Meta-analysis of prostate cancer gene expression data identifies a novel discriminatory signature enriched for glycosylating enzymes

Table 4 KEGG pathway enrichment analysis for the genes comprising signature 3 (101.6.4)

Category	Term	Count	%	PValue	Genes	List Total	Pop Hits	Pop Total	Fold Enrichment	Bonferroni	Benjamini	FDR
KEGG_PATHWAY	hsa00100:Steroid biosynthesis	3	0.1	0.03	SQLE, FDFT1, SC4MOL	86	17	5085	10.43	0.97	0.97	30.81
KEGG_PATHWAY	hsa05200:Pathways in cancer	11	0.38	0.05	LAMA1, HRAS, PTK2, SOS1, CBL, VEGFA, PPARG, RALA, LEF1, MDM2, LAMB1	86	328	5085	1.98	0.99	0.93	41.08
KEGG_PATHWAY	hsa04510:Focal adhesion	8	0.27	0.05	LAMA1, HRAS, PTK2, FLT1, DIAPH1, SOS1, VEGFA, LAMB1	86	201	5085	2.35	1	0.85	44.04
KEGG_PATHWAY	hsa00330:Arginine and proline metabolism	4	0.14	0.06	ARG1, P4HA2, P4HA1, CPS1	86	53	5085	4.46	1	0.82	49.31
KEGG_PATHWAY	hsa05216:Thyroid cancer	3	0.1	0.08	HRAS, PPARG, LEF1	86	29	5085	6.12	1	0.86	63

Genes comprising signature 4 (Additional file 8: Table S6) were uploaded into the DAVID gene ontology search engine (http://david.abcc.ncifcrf.gov/). KEGG pathway enrichment was generated and the table represents the output file ranked based on significance and annotated by column header.

ISSN: 1755-8794