Meta-analysis of prostate cancer gene expression data identifies a novel discriminatory signature enriched for glycosylating enzymes

Table 7 Overexpressed genes in localised prostate cancer versus benign tissue within the entire set of differentially expressed genes in the Varambally dataset (GSE3325)

Gene/signature	AUC benign-local	AUC benign-metastatic	AUC localized-metastatic
KLK3	0.5204082	0.9104938	0.8707483
ERG	0.812616	0.9326599	0.6099773
AR	0.6581633	0.8395062	0.8435374
31 Gene signature	0.994898	0.9938272	0.957672
Derived from the Grasso Data

Genes overexpressed in localised prostate cancer are ranked according to the degree of overexpression from highest to lowest within dataset GSE3325. Genes highlighted in bold are also overexpressed in at least three other independent prostate cancer expression array datasets hosted by the Oncomine compendium (http://www.oncomine.org) within the Top 1% of overexpressed gene transcripts in all cases.

ISSN: 1755-8794