Table 3 Pathways enriched/depleted in differentially regulated genes correlating with CREDI and INSCO

Hedgehog signaling pathway

3

0.002

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade

3

0.006

Formyltetrahydroformate biosynthesis

2

0.006

PDGF signaling pathway

6

0.006

TGF-beta signaling pathway

5

0.018

Transcription regulation by bZIP transcription factor

3

0.018

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

3

0.027

Ornithine degradation

1

0.030

Integrin signaling pathway

5

0.040

Serine glycine biosynthesis

1

0.050

Downregulated genes (n = 340)

Pathways

# genes

P value

ATP synthesis

4

0.000

FGF signaling pathway

8

0.001

EGF receptor signaling pathway

8

0.002

GABA-B_receptor_II_signaling

4

0.004

Alzheimer disease-amyloid secretase pathway

5

0.006

T cell activation

6

0.006

Endogenous_cannabinoid_signaling

3

0.007

Histamine H1 receptor mediated signaling pathway

4

0.007

Metabotropic glutamate receptor group II pathway

4

0.009

B cell activation

5

0.010

Axon guidance mediated by netrin

3

0.012

Endothelin signaling pathway

5

0.015

Oxytocin receptor mediated signaling pathway

4

0.016

Thyrotropin-releasing hormone receptor signaling pathway

4

0.018

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

4

0.018

Cholesterol biosynthesis

2

0.018

Metabotropic glutamate receptor group I pathway

3

0.020

5HT2 type receptor mediated signaling pathway

4

0.025

Succinate to proprionate conversion

1

0.031

VEGF signaling pathway

4

0.032

5HT1 type receptor mediated signaling pathway

3

0.033

Angiogenesis

7

0.033

Inflammation mediated by chemokine and cytokine signaling pathway

9

0.037

PDGF signaling pathway

6

0.042

DNA replication

2

0.044

Cell cycle

2

0.048

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

6

0.050

Upregulated genes (n = 150)

Pathways

# Genes

P value

Chorismate biosynthesis

1

0.000

Nicotinic acetylcholine receptor signaling pathway

3

0.033

Mannose metabolism

1

0.049

Downregulated genes (n = 135)

Pathways

# Genes

P value

mRNA splicing

2

0.002

General transcription by RNA polymerase I

2

0.007

PLP biosynthesis

1

0.013

Leucine biosynthesis

1

0.013

Alanine biosynthesis

1

0.013

Vitamin B6 metabolism

1

0.019

Valine biosynthesis

1

0.019

Isoleucine biosynthesis

1

0.019

PDGF signaling pathway

4

0.019

Serine glycine biosynthesis

1

0.031

Histamine H1 receptor mediated signaling pathway

2

0.037

p53 pathway feedback loops 2

2

0.044

Apoptosis signaling pathway

3

0.045