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Table 2 Survival analysis of grade 1 and 3 tumors classified with fuzzy molecular and histologic grades

From: Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer – the INNODIAG study

fuzzy Gene Signature

HG 1&3 patients

fuzzy Gene Signatures

Histologic grade

n

Hazard Ratio (95% CI)

p value logrank test

Hazard Ratio (95% CI)

p value logrank test

f MG A

     

NKI2 training

113

2.136 (1.466 - 3.113)

<.001

1.5896 (1.135 - 2.213)

<0.0052

NKI2 validation all

163

1.989 (1.463 - 2.704)

<.001

1.694 (1.294 - 2.218)

<.001

f MG B

     

KJX64/KJ125 training

99

1.923 (1.342 - 2.754)

<.001

1.546 (1.075 - 2.223)

<0.0184

Transbig

113

1.435 (1.005 - 2.051)

<0.0426

1.062 (0.792 - 1.426)

=0.0541

Stockholm

89

2.711 (1.313 - 5.595)

<0.00158

2.104 (1.28 - 3.459)

<0.0103

Pool 1

272

1.59 (1.25 to 2,02)

<0.0001

1.55 (1.20 to 2.00)

<0.001

f MG C

     

Uppsala training

123

1.484 (1.091 - 2.017)

<0.0103

1.773 (1.306 - 2.408)

<.001

Stockholm

89

4.134 (1.518 - 11.258)

<.001

2.104 (1.28 - 3.459)

<0.0103

f MG D

     

Transbig Training

113

1.28 (0.852 - 1.923)

=0.23

1.062 (0.792 - 1.426)

=0.0541

KJX64/KJ125

122

1.591 (1.157 - 2.186)

<0.00312

1.518 (1.11 - 2.077)

<0.00725

Stockholm

89

3.844 (1.412 - 10.469)

<.001

2.104 (1.28 - 3.459)

<0.0103

Pool 2

281

1.65 (1.31 to 2,07) supp KJX

<0.00001

1.66 (1.32 to 2.09)

<0.00001

  1. Pool 1: Uppsala + Transbig + Stockholm.
  2. Pool 2: KJX64/KJ125 + Uppsala + Stockholm.