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Table 2 Survival analysis of grade 1 and 3 tumors classified with fuzzy molecular and histologic grades

From: Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer – the INNODIAG study

fuzzy Gene Signature HG 1&3 patients fuzzy Gene Signatures Histologic grade
n Hazard Ratio (95% CI) p value logrank test Hazard Ratio (95% CI) p value logrank test
f MG A      
NKI2 training 113 2.136 (1.466 - 3.113) <.001 1.5896 (1.135 - 2.213) <0.0052
NKI2 validation all 163 1.989 (1.463 - 2.704) <.001 1.694 (1.294 - 2.218) <.001
f MG B      
KJX64/KJ125 training 99 1.923 (1.342 - 2.754) <.001 1.546 (1.075 - 2.223) <0.0184
Transbig 113 1.435 (1.005 - 2.051) <0.0426 1.062 (0.792 - 1.426) =0.0541
Stockholm 89 2.711 (1.313 - 5.595) <0.00158 2.104 (1.28 - 3.459) <0.0103
Pool 1 272 1.59 (1.25 to 2,02) <0.0001 1.55 (1.20 to 2.00) <0.001
f MG C      
Uppsala training 123 1.484 (1.091 - 2.017) <0.0103 1.773 (1.306 - 2.408) <.001
Stockholm 89 4.134 (1.518 - 11.258) <.001 2.104 (1.28 - 3.459) <0.0103
f MG D      
Transbig Training 113 1.28 (0.852 - 1.923) =0.23 1.062 (0.792 - 1.426) =0.0541
KJX64/KJ125 122 1.591 (1.157 - 2.186) <0.00312 1.518 (1.11 - 2.077) <0.00725
Stockholm 89 3.844 (1.412 - 10.469) <.001 2.104 (1.28 - 3.459) <0.0103
Pool 2 281 1.65 (1.31 to 2,07) supp KJX <0.00001 1.66 (1.32 to 2.09) <0.00001
  1. Pool 1: Uppsala + Transbig + Stockholm.
  2. Pool 2: KJX64/KJ125 + Uppsala + Stockholm.