Weighted gene co-expression analysis of adipose tissue transcript in adipose tissue from Caucasian (CA) subjects identified gene networks (modules) associated with gluco-metabolic phenotypes. A) Topological Overlap Matrix (TOM) plot of the adipose tissue expression network connections in 99 CA subjects. Light color represents low topological overlap and progressively darker red color represents higher overlap. Each module is assigned by unique color; these are shown along the left side and the top, B) Correlation heatmap of 93 module eigengenes and 12 gluco-metabolic traits, C) A Circos plot showing module names (Ring 1), module color representation (Ring 2), correlations between module eigengenes and insulin sensitivity (SI) (Ring 3), with the bar height representing absolute value of correlation coefficient (range = [0.0012,0.53]) and the bar color for the correlation sign (red – positive and green – negative), module specificity to CA (high bar – CA-specific and low bar – not CA-specific) (Ring 4), significance of the enrichment for up-regulated genes in AAs with the bar height representing –log10(FET p value) (Ring 5) (range = [2.2e-39,1]), significance of the enrichment for down-regulated genes in AAs with the bar height representing –log10(FET p value) (Ring 6) (range = [5.8e-6,1]), and significance of the best enrichment for the modules in AA with the bar height representing –log10(FET p value) (Ring 7) (range = [0, 0.015]). The module names and color representations match those in Figure 3A. The modules are sorted based on the correlations between the module eigengenes and SI.