Figure 4
Weighted gene co-expression analysis of adipose tissue transcript in adipose tissue identified distinct pattern of association between gene networks (modules) and gluco-metabolic phenotypes in African American subjects. A) TOM plot of the adipose tissue indicates distinct expression network connections in 37 AA subjects. Light color represents low topological overlap and progressively darker red color represents higher overlap. Each module is assigned by unique color; these are shown along the left side and the top, B) Correlation heatmap of 173 module eigengenes and 12 gluco-metabolic traits, C) A Circos plot showing module names (Ring 1), module color representation (Ring 2), correlations between module eigengenes and insulin sensitivity (SI) (Ring 3), with the bar height representing absolute value of correlation coefficient (range = [0.0033,0.61]) and the bar color for the correlation sign (red – positive and green – negative), module specificity to AA (high bar – AA-specific and low bar – not AA-specific) (Ring 4), significance of the enrichment for up-regulated genes in AAs with the bar height representing–log10(FET p value) (Ring 5) (range = [8.2e-19,1]), significance of the enrichment for down-regulated genes in AAs with the bar height representing –log10(FET p value) (Ring 6) (range = [1.8e-7,1]), and significance of the best enrichment for the modules in CA with the bar height representing–log10(FET p value) (Ring 7) (range = [0, 0.13]). The module names and color representations match those in Figure 4A. The modules are sorted based on the correlations between the module eigengenes and SI.