The “light yellow” module is an African American-specific insulin sensitivity (S
)-associated network module. A) Network plots of the “light yellow” module in adipose of AA subjects. The red nodes are “drivers”; the size of a node is proportional to the number of nodes in the node's 2-layer neighborhood, B) Enrichment of module genes for canonical pathways in IPA analysis, C) The most significant network among the module members based on IPA interaction network analysis involves the YWHAE (14-3-3) gene. Genes positively or negatively correlated with SI in this interaction network are shown in red and green, respectively.