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Table 4 Insulin sensitivity associated co-expression modules in adipose tissue of Caucasian subjects shows differential connectivity

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

Module (Module size) MDC MDC FDR AA.DE Overlap (P-value) S I correlation (p-value) BMI correlation (p-value) GO Gene Category Overlap, p-value
Bisque (121) 11.16 0 3 −0.323 0.357 Response to virus
(NS) (0.04) (0.11) 23, 6.70E-26
Green (487) 4.34 0 9 0.337 −0.593 Ribosome
(NS) (0.01) (1.35E-06) 27, 5.60E-17
Khaki (134) 4.13 0 4 0.284 −0.322 Lipid metabolism
(NS) (7.48E-04) (5.24E-03) 39, 1.7E-25
Pink (359) 3.02 0 15 0.411 −0.491 Mitochondrion
(NS) (3.53E-04) (9.73E-07) 87, 3.6E-59
Gray7 (15) 2.8 0.02 5 −0.264 0.458 Adherens junction
(1.03E-05) (0.01) (1.34E-06) 2, 0.00014
Green4 (22) 2.37 0.04 0 −0.233 0.378 IL4 - antiapoptotic action
(NS) (0.04) (2.23E-04) 2, 0.00034
Red2 (43) 2.03 0 0 0.385 −0.34 Mitochondrion
(NS) (7.72E-05) (5.42E-04) 6, 0.0011
Wheat (157) 2.02 0 12 0.192 −0.101 Mitochondrion
(6.36E-03) (0.03) (0.20) 21, 1.40E-10
Gray3 (16) 1.91 0.04 1 0.38 −0.392 Guanylate kinase activity
(NS) (4.42E-04) (1.09E-05) 2, 2.60E-05
Peru (167) 1.46 0 10 −0.423 0.683 Steroid metabolism
(0.05) (6.02E-04) (1.45E-12) 10, 5.90E-06
Thistle (88) 1.23 0.04 4 −0.531 0.662 Cellular defense response
(NS) (2.89E-06) (1.67E-12) 6, 3.90E-05
Tan (268) 1.11 0 4 0.463 −0.677 Enoyl-CoA hydratase activity
(NS) (1.02E-04) (6.73E-13) 3, 4.60E-05
Light yellow (186) 1 0.04 2 0.413 −0.409 Mitochondrion
(NS) (7.31E-06) (1.59E-05) 27, 1.1E-11
  1. MDC, modular differential connectivity; FDR, false discovery rate; SI, insulin sensitivity derived from MINMOD analysis of FSIVGT; AA.DE, genes differentially expressed in AA compared to CA subjects.