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Table 4 Insulin sensitivity associated co-expression modules in adipose tissue of Caucasian subjects shows differential connectivity

From: Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

Module (Module size)

MDC

MDC FDR

AA.DE Overlap (P-value)

S I correlation (p-value)

BMI correlation (p-value)

GO Gene Category Overlap, p-value

Bisque (121)

11.16

0

3

−0.323

0.357

Response to virus

(NS)

(0.04)

(0.11)

23, 6.70E-26

Green (487)

4.34

0

9

0.337

−0.593

Ribosome

(NS)

(0.01)

(1.35E-06)

27, 5.60E-17

Khaki (134)

4.13

0

4

0.284

−0.322

Lipid metabolism

(NS)

(7.48E-04)

(5.24E-03)

39, 1.7E-25

Pink (359)

3.02

0

15

0.411

−0.491

Mitochondrion

(NS)

(3.53E-04)

(9.73E-07)

87, 3.6E-59

Gray7 (15)

2.8

0.02

5

−0.264

0.458

Adherens junction

(1.03E-05)

(0.01)

(1.34E-06)

2, 0.00014

Green4 (22)

2.37

0.04

0

−0.233

0.378

IL4 - antiapoptotic action

(NS)

(0.04)

(2.23E-04)

2, 0.00034

Red2 (43)

2.03

0

0

0.385

−0.34

Mitochondrion

(NS)

(7.72E-05)

(5.42E-04)

6, 0.0011

Wheat (157)

2.02

0

12

0.192

−0.101

Mitochondrion

(6.36E-03)

(0.03)

(0.20)

21, 1.40E-10

Gray3 (16)

1.91

0.04

1

0.38

−0.392

Guanylate kinase activity

(NS)

(4.42E-04)

(1.09E-05)

2, 2.60E-05

Peru (167)

1.46

0

10

−0.423

0.683

Steroid metabolism

(0.05)

(6.02E-04)

(1.45E-12)

10, 5.90E-06

Thistle (88)

1.23

0.04

4

−0.531

0.662

Cellular defense response

(NS)

(2.89E-06)

(1.67E-12)

6, 3.90E-05

Tan (268)

1.11

0

4

0.463

−0.677

Enoyl-CoA hydratase activity

(NS)

(1.02E-04)

(6.73E-13)

3, 4.60E-05

Light yellow (186)

1

0.04

2

0.413

−0.409

Mitochondrion

(NS)

(7.31E-06)

(1.59E-05)

27, 1.1E-11

  1. MDC, modular differential connectivity; FDR, false discovery rate; SI, insulin sensitivity derived from MINMOD analysis of FSIVGT; AA.DE, genes differentially expressed in AA compared to CA subjects.